Proliferative activity of antigen-specific CD154+ T cells against bacterial and fungal respiratory pathogens in cystic fibrosis decreases after initiation of highly effective CFTR modulator therapy

Background: Together with impaired mucociliary clearance, lung disease in cystic fibrosis (CF) is driven by dysregulation of innate and adaptive immunity caused by dysfunctional CFTR (Cystic Fibrosis Transmembrane Conductance Regulator), leading to airway infection and hyperinflamma-tion. The highly...

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Detalles Bibliográficos
Autores principales: Eschenhagen, Patience N., Bacher, Petra, Grehn, Claudia, Mainz, Jochen G., Scheffold, Alexander, Schwarz, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318131/
https://www.ncbi.nlm.nih.gov/pubmed/37408761
http://dx.doi.org/10.3389/fphar.2023.1180826

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