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Emerging Therapeutic Strategies in The Fight Against Primary Biliary Cholangitis
The liver has a vital role in many metabolic and regulatory processes in the body. Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a chronic cholestatic autoimmune disease of the intrahepatic bile ducts associated with loss of tolerance to mitochondrial antigens....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
XIA & HE Publishing Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318288/ https://www.ncbi.nlm.nih.gov/pubmed/37408803 http://dx.doi.org/10.14218/JCTH.2022.00398 |
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author | Medford, Abigail Childs, Jonathan Little, Ashleigh Chakraborty, Sanjukta Baiocchi, Leonardo Alpini, Gianfranco Glaser, Shannon |
author_facet | Medford, Abigail Childs, Jonathan Little, Ashleigh Chakraborty, Sanjukta Baiocchi, Leonardo Alpini, Gianfranco Glaser, Shannon |
author_sort | Medford, Abigail |
collection | PubMed |
description | The liver has a vital role in many metabolic and regulatory processes in the body. Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a chronic cholestatic autoimmune disease of the intrahepatic bile ducts associated with loss of tolerance to mitochondrial antigens. At this time there is no definitive cure for PBC; however, ursodeoxycholic acid (UDCA) has been shown to reduce injury when administered as the first line of treatment. Additional therapeutics can be given concurrently or as an alternative to UDCA to manage the symptoms and further curb disease progression. Currently, a liver transplant is the only potentially curative option when the patient has developed end-stage liver disease or intractable pruritus. This review aims to delineate the pathogenesis of primary biliary cholangitis and shed light on current therapeutic strategies in the treatment of PBC. |
format | Online Article Text |
id | pubmed-10318288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | XIA & HE Publishing Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103182882023-07-05 Emerging Therapeutic Strategies in The Fight Against Primary Biliary Cholangitis Medford, Abigail Childs, Jonathan Little, Ashleigh Chakraborty, Sanjukta Baiocchi, Leonardo Alpini, Gianfranco Glaser, Shannon J Clin Transl Hepatol Review Article The liver has a vital role in many metabolic and regulatory processes in the body. Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a chronic cholestatic autoimmune disease of the intrahepatic bile ducts associated with loss of tolerance to mitochondrial antigens. At this time there is no definitive cure for PBC; however, ursodeoxycholic acid (UDCA) has been shown to reduce injury when administered as the first line of treatment. Additional therapeutics can be given concurrently or as an alternative to UDCA to manage the symptoms and further curb disease progression. Currently, a liver transplant is the only potentially curative option when the patient has developed end-stage liver disease or intractable pruritus. This review aims to delineate the pathogenesis of primary biliary cholangitis and shed light on current therapeutic strategies in the treatment of PBC. XIA & HE Publishing Inc. 2023-08-28 2023-03-16 /pmc/articles/PMC10318288/ /pubmed/37408803 http://dx.doi.org/10.14218/JCTH.2022.00398 Text en © 2023 Authors. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Medford, Abigail Childs, Jonathan Little, Ashleigh Chakraborty, Sanjukta Baiocchi, Leonardo Alpini, Gianfranco Glaser, Shannon Emerging Therapeutic Strategies in The Fight Against Primary Biliary Cholangitis |
title | Emerging Therapeutic Strategies in The Fight Against Primary Biliary Cholangitis |
title_full | Emerging Therapeutic Strategies in The Fight Against Primary Biliary Cholangitis |
title_fullStr | Emerging Therapeutic Strategies in The Fight Against Primary Biliary Cholangitis |
title_full_unstemmed | Emerging Therapeutic Strategies in The Fight Against Primary Biliary Cholangitis |
title_short | Emerging Therapeutic Strategies in The Fight Against Primary Biliary Cholangitis |
title_sort | emerging therapeutic strategies in the fight against primary biliary cholangitis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318288/ https://www.ncbi.nlm.nih.gov/pubmed/37408803 http://dx.doi.org/10.14218/JCTH.2022.00398 |
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