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Alteration of brain function and systemic inflammatory tone in older adults by decreasing the dietary palmitic acid intake
Prior studies in younger adults showed that reducing the normally high intake of the saturated fatty acid, palmitic acid (PA), in the North American diet by replacing it with the monounsaturated fatty acid, oleic acid (OA), decreased blood concentrations and secretion by peripheral blood mononuclear...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318304/ https://www.ncbi.nlm.nih.gov/pubmed/37408793 http://dx.doi.org/10.1016/j.nbas.2023.100072 |
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author | Dumas, Julie A. Bunn, Janice Y. LaMantia, Michael A. McIsaac, Catherine Senft Miller, Anna Nop, Olivia Testo, Abigail Soares, Bruno P. Mank, Madeleine M. Poynter, Matthew E. Lawrence Kien, C. |
author_facet | Dumas, Julie A. Bunn, Janice Y. LaMantia, Michael A. McIsaac, Catherine Senft Miller, Anna Nop, Olivia Testo, Abigail Soares, Bruno P. Mank, Madeleine M. Poynter, Matthew E. Lawrence Kien, C. |
author_sort | Dumas, Julie A. |
collection | PubMed |
description | Prior studies in younger adults showed that reducing the normally high intake of the saturated fatty acid, palmitic acid (PA), in the North American diet by replacing it with the monounsaturated fatty acid, oleic acid (OA), decreased blood concentrations and secretion by peripheral blood mononuclear cells (PBMCs) of interleukin (IL)-1β and IL-6 and changed brain activation in regions of the working memory network. We examined the effects of these fatty acid manipulations in the diet of older adults. Ten subjects, aged 65–75 years, participated in a randomized, cross-over trial comparing 1-week high PA versus low PA/high OA diets. We evaluated functional magnetic resonance imaging (fMRI) using an N-back test of working memory and a resting state scan, cytokine secretion by lipopolysaccharide (LPS)-stimulated PBMCs, and plasma cytokine concentrations. During the low PA compared to the high PA diet, we observed increased activation for the 2-back minus 0-back conditions in the right dorsolateral prefrontal cortex (Broadman Area (BA) 9; p < 0.005), but the effect of diet on working memory performance was not significant (p = 0.09). We observed increased connectivity between anterior regions of the salience network during the low PA/high OA diet (p < 0.001). The concentrations of IL-1β (p = 0.026), IL-8 (p = 0.013), and IL-6 (p = 0.009) in conditioned media from LPS-stimulated PBMCs were lower during the low PA/high OA diet. This study suggests that lowering the dietary intake of PA down-regulated pro-inflammatory cytokine secretion and altered working memory, task-based activation and resting state functional connectivity in older adults. |
format | Online Article Text |
id | pubmed-10318304 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103183042023-07-05 Alteration of brain function and systemic inflammatory tone in older adults by decreasing the dietary palmitic acid intake Dumas, Julie A. Bunn, Janice Y. LaMantia, Michael A. McIsaac, Catherine Senft Miller, Anna Nop, Olivia Testo, Abigail Soares, Bruno P. Mank, Madeleine M. Poynter, Matthew E. Lawrence Kien, C. Aging Brain Article Prior studies in younger adults showed that reducing the normally high intake of the saturated fatty acid, palmitic acid (PA), in the North American diet by replacing it with the monounsaturated fatty acid, oleic acid (OA), decreased blood concentrations and secretion by peripheral blood mononuclear cells (PBMCs) of interleukin (IL)-1β and IL-6 and changed brain activation in regions of the working memory network. We examined the effects of these fatty acid manipulations in the diet of older adults. Ten subjects, aged 65–75 years, participated in a randomized, cross-over trial comparing 1-week high PA versus low PA/high OA diets. We evaluated functional magnetic resonance imaging (fMRI) using an N-back test of working memory and a resting state scan, cytokine secretion by lipopolysaccharide (LPS)-stimulated PBMCs, and plasma cytokine concentrations. During the low PA compared to the high PA diet, we observed increased activation for the 2-back minus 0-back conditions in the right dorsolateral prefrontal cortex (Broadman Area (BA) 9; p < 0.005), but the effect of diet on working memory performance was not significant (p = 0.09). We observed increased connectivity between anterior regions of the salience network during the low PA/high OA diet (p < 0.001). The concentrations of IL-1β (p = 0.026), IL-8 (p = 0.013), and IL-6 (p = 0.009) in conditioned media from LPS-stimulated PBMCs were lower during the low PA/high OA diet. This study suggests that lowering the dietary intake of PA down-regulated pro-inflammatory cytokine secretion and altered working memory, task-based activation and resting state functional connectivity in older adults. Elsevier 2023-03-10 /pmc/articles/PMC10318304/ /pubmed/37408793 http://dx.doi.org/10.1016/j.nbas.2023.100072 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Dumas, Julie A. Bunn, Janice Y. LaMantia, Michael A. McIsaac, Catherine Senft Miller, Anna Nop, Olivia Testo, Abigail Soares, Bruno P. Mank, Madeleine M. Poynter, Matthew E. Lawrence Kien, C. Alteration of brain function and systemic inflammatory tone in older adults by decreasing the dietary palmitic acid intake |
title | Alteration of brain function and systemic inflammatory tone in older adults by decreasing the dietary palmitic acid intake |
title_full | Alteration of brain function and systemic inflammatory tone in older adults by decreasing the dietary palmitic acid intake |
title_fullStr | Alteration of brain function and systemic inflammatory tone in older adults by decreasing the dietary palmitic acid intake |
title_full_unstemmed | Alteration of brain function and systemic inflammatory tone in older adults by decreasing the dietary palmitic acid intake |
title_short | Alteration of brain function and systemic inflammatory tone in older adults by decreasing the dietary palmitic acid intake |
title_sort | alteration of brain function and systemic inflammatory tone in older adults by decreasing the dietary palmitic acid intake |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318304/ https://www.ncbi.nlm.nih.gov/pubmed/37408793 http://dx.doi.org/10.1016/j.nbas.2023.100072 |
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