A novel biguanide derivative, IM176, induces prostate cancer cell death by modulating the AMPK-mTOR and androgen receptor signaling pathways

BACKGROUND: Metformin and phenformin, biguanide derivatives that are widely used to treat type 2 diabetes mellitus, have recently been shown to exert potential anticancer effects in prostate cancer. This study compared the antiprostate cancer effects of the novel biguanide derivative IM176 with thos...

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Detalles Bibliográficos
Autores principales: Kim, Yunlim, Yoo, Sangjun, Lim, Bumjin, Hong, Jun Hyuk, Kwak, Cheol, You, Dalsan, Hwang, Jung Jin, Kim, Choung-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asian Pacific Prostate Society 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318334/
https://www.ncbi.nlm.nih.gov/pubmed/37409095
http://dx.doi.org/10.1016/j.prnil.2022.11.003

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