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Evaluation of an ivermectin-based attractive targeted sugar bait (ATSB) against Aedes aegypti in Tanzania.

Background The control of vector borne arboviral diseases such as Dengue is mainly achieved by reducing human-vector contact and controlling the vectors through source reduction and environmental management. These measures are constrained by labour intensity, insecticide resistance and pro-active co...

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Autores principales: Tenywa, Frank Sandra Chelestino, Musa, Jeremiah John, Musiba, Revocatus Musyangi, Swai, Johnson Kyeba, Mpelepele, Ahmad Bakar, Okumu, Fredros Okech, Maia, Marta Ferreira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318376/
https://www.ncbi.nlm.nih.gov/pubmed/37409221
http://dx.doi.org/10.12688/wellcomeopenres.17442.1
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author Tenywa, Frank Sandra Chelestino
Musa, Jeremiah John
Musiba, Revocatus Musyangi
Swai, Johnson Kyeba
Mpelepele, Ahmad Bakar
Okumu, Fredros Okech
Maia, Marta Ferreira
author_facet Tenywa, Frank Sandra Chelestino
Musa, Jeremiah John
Musiba, Revocatus Musyangi
Swai, Johnson Kyeba
Mpelepele, Ahmad Bakar
Okumu, Fredros Okech
Maia, Marta Ferreira
author_sort Tenywa, Frank Sandra Chelestino
collection PubMed
description Background The control of vector borne arboviral diseases such as Dengue is mainly achieved by reducing human-vector contact and controlling the vectors through source reduction and environmental management. These measures are constrained by labour intensity, insecticide resistance and pro-active community participation. The current study intended to develop and test an ivermectin-based attractive-targeted sugar bait (ATSB) against Aedes aegypti. Methods The 48hour lethal concentration (LC90) of ivermectin against Ae. aegypti was determined through serial dilution experiment where five 30cm x 30cm x 30cm cages were set; into each, a 10% sugar solution treated with ivermectin were introduced. 40 Ae. aegypti were released into each cage and observed for mortality after 4, 8, 24 and 48 hours. The ivermectin-based ATSB was evaluated in a semi field system where ATSB and attractive sugar bait (ASB) were deployed into each compartment of the semi field and 100 female Ae. aegypti were released every day and recaptured the next day through human land catch and Bio-gent sentinel trap. The developed and semi-field tested ATSB was further tested in the field by deploying them in garages. Results The ivermectin 48hr LC90 of male and female Ae. aegypti was found to be 0.03% w/v. In the semi field system, the ATSB significantly reduced a free-flying population of Ae. aegypti within 24 hours (incidence rate ratio (IRR) = 0.62; [95% confidence interval (95%CI); 0.54-0.70] and p-value < 0.001). However, in the field, the ATSBs required the addition of yeast as a carbon dioxide source to efficiently attract Ae. aegypti mosquitoes to feed. Conclusion Ivermectin is an active ingredient that can be used in an ATSB for Ae. aegypti depopulation. However, further research is needed to improve the developed and tested ATSB to compete with natural sources of sugar in a natural environment.
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spelling pubmed-103183762023-07-05 Evaluation of an ivermectin-based attractive targeted sugar bait (ATSB) against Aedes aegypti in Tanzania. Tenywa, Frank Sandra Chelestino Musa, Jeremiah John Musiba, Revocatus Musyangi Swai, Johnson Kyeba Mpelepele, Ahmad Bakar Okumu, Fredros Okech Maia, Marta Ferreira Wellcome Open Res Research Article Background The control of vector borne arboviral diseases such as Dengue is mainly achieved by reducing human-vector contact and controlling the vectors through source reduction and environmental management. These measures are constrained by labour intensity, insecticide resistance and pro-active community participation. The current study intended to develop and test an ivermectin-based attractive-targeted sugar bait (ATSB) against Aedes aegypti. Methods The 48hour lethal concentration (LC90) of ivermectin against Ae. aegypti was determined through serial dilution experiment where five 30cm x 30cm x 30cm cages were set; into each, a 10% sugar solution treated with ivermectin were introduced. 40 Ae. aegypti were released into each cage and observed for mortality after 4, 8, 24 and 48 hours. The ivermectin-based ATSB was evaluated in a semi field system where ATSB and attractive sugar bait (ASB) were deployed into each compartment of the semi field and 100 female Ae. aegypti were released every day and recaptured the next day through human land catch and Bio-gent sentinel trap. The developed and semi-field tested ATSB was further tested in the field by deploying them in garages. Results The ivermectin 48hr LC90 of male and female Ae. aegypti was found to be 0.03% w/v. In the semi field system, the ATSB significantly reduced a free-flying population of Ae. aegypti within 24 hours (incidence rate ratio (IRR) = 0.62; [95% confidence interval (95%CI); 0.54-0.70] and p-value < 0.001). However, in the field, the ATSBs required the addition of yeast as a carbon dioxide source to efficiently attract Ae. aegypti mosquitoes to feed. Conclusion Ivermectin is an active ingredient that can be used in an ATSB for Ae. aegypti depopulation. However, further research is needed to improve the developed and tested ATSB to compete with natural sources of sugar in a natural environment. F1000 Research Limited 2022-01-05 /pmc/articles/PMC10318376/ /pubmed/37409221 http://dx.doi.org/10.12688/wellcomeopenres.17442.1 Text en Copyright: © 2022 Tenywa FSC et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tenywa, Frank Sandra Chelestino
Musa, Jeremiah John
Musiba, Revocatus Musyangi
Swai, Johnson Kyeba
Mpelepele, Ahmad Bakar
Okumu, Fredros Okech
Maia, Marta Ferreira
Evaluation of an ivermectin-based attractive targeted sugar bait (ATSB) against Aedes aegypti in Tanzania.
title Evaluation of an ivermectin-based attractive targeted sugar bait (ATSB) against Aedes aegypti in Tanzania.
title_full Evaluation of an ivermectin-based attractive targeted sugar bait (ATSB) against Aedes aegypti in Tanzania.
title_fullStr Evaluation of an ivermectin-based attractive targeted sugar bait (ATSB) against Aedes aegypti in Tanzania.
title_full_unstemmed Evaluation of an ivermectin-based attractive targeted sugar bait (ATSB) against Aedes aegypti in Tanzania.
title_short Evaluation of an ivermectin-based attractive targeted sugar bait (ATSB) against Aedes aegypti in Tanzania.
title_sort evaluation of an ivermectin-based attractive targeted sugar bait (atsb) against aedes aegypti in tanzania.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318376/
https://www.ncbi.nlm.nih.gov/pubmed/37409221
http://dx.doi.org/10.12688/wellcomeopenres.17442.1
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