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Evaluation of an ivermectin-based attractive targeted sugar bait (ATSB) against Aedes aegypti in Tanzania.
Background The control of vector borne arboviral diseases such as Dengue is mainly achieved by reducing human-vector contact and controlling the vectors through source reduction and environmental management. These measures are constrained by labour intensity, insecticide resistance and pro-active co...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318376/ https://www.ncbi.nlm.nih.gov/pubmed/37409221 http://dx.doi.org/10.12688/wellcomeopenres.17442.1 |
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author | Tenywa, Frank Sandra Chelestino Musa, Jeremiah John Musiba, Revocatus Musyangi Swai, Johnson Kyeba Mpelepele, Ahmad Bakar Okumu, Fredros Okech Maia, Marta Ferreira |
author_facet | Tenywa, Frank Sandra Chelestino Musa, Jeremiah John Musiba, Revocatus Musyangi Swai, Johnson Kyeba Mpelepele, Ahmad Bakar Okumu, Fredros Okech Maia, Marta Ferreira |
author_sort | Tenywa, Frank Sandra Chelestino |
collection | PubMed |
description | Background The control of vector borne arboviral diseases such as Dengue is mainly achieved by reducing human-vector contact and controlling the vectors through source reduction and environmental management. These measures are constrained by labour intensity, insecticide resistance and pro-active community participation. The current study intended to develop and test an ivermectin-based attractive-targeted sugar bait (ATSB) against Aedes aegypti. Methods The 48hour lethal concentration (LC90) of ivermectin against Ae. aegypti was determined through serial dilution experiment where five 30cm x 30cm x 30cm cages were set; into each, a 10% sugar solution treated with ivermectin were introduced. 40 Ae. aegypti were released into each cage and observed for mortality after 4, 8, 24 and 48 hours. The ivermectin-based ATSB was evaluated in a semi field system where ATSB and attractive sugar bait (ASB) were deployed into each compartment of the semi field and 100 female Ae. aegypti were released every day and recaptured the next day through human land catch and Bio-gent sentinel trap. The developed and semi-field tested ATSB was further tested in the field by deploying them in garages. Results The ivermectin 48hr LC90 of male and female Ae. aegypti was found to be 0.03% w/v. In the semi field system, the ATSB significantly reduced a free-flying population of Ae. aegypti within 24 hours (incidence rate ratio (IRR) = 0.62; [95% confidence interval (95%CI); 0.54-0.70] and p-value < 0.001). However, in the field, the ATSBs required the addition of yeast as a carbon dioxide source to efficiently attract Ae. aegypti mosquitoes to feed. Conclusion Ivermectin is an active ingredient that can be used in an ATSB for Ae. aegypti depopulation. However, further research is needed to improve the developed and tested ATSB to compete with natural sources of sugar in a natural environment. |
format | Online Article Text |
id | pubmed-10318376 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-103183762023-07-05 Evaluation of an ivermectin-based attractive targeted sugar bait (ATSB) against Aedes aegypti in Tanzania. Tenywa, Frank Sandra Chelestino Musa, Jeremiah John Musiba, Revocatus Musyangi Swai, Johnson Kyeba Mpelepele, Ahmad Bakar Okumu, Fredros Okech Maia, Marta Ferreira Wellcome Open Res Research Article Background The control of vector borne arboviral diseases such as Dengue is mainly achieved by reducing human-vector contact and controlling the vectors through source reduction and environmental management. These measures are constrained by labour intensity, insecticide resistance and pro-active community participation. The current study intended to develop and test an ivermectin-based attractive-targeted sugar bait (ATSB) against Aedes aegypti. Methods The 48hour lethal concentration (LC90) of ivermectin against Ae. aegypti was determined through serial dilution experiment where five 30cm x 30cm x 30cm cages were set; into each, a 10% sugar solution treated with ivermectin were introduced. 40 Ae. aegypti were released into each cage and observed for mortality after 4, 8, 24 and 48 hours. The ivermectin-based ATSB was evaluated in a semi field system where ATSB and attractive sugar bait (ASB) were deployed into each compartment of the semi field and 100 female Ae. aegypti were released every day and recaptured the next day through human land catch and Bio-gent sentinel trap. The developed and semi-field tested ATSB was further tested in the field by deploying them in garages. Results The ivermectin 48hr LC90 of male and female Ae. aegypti was found to be 0.03% w/v. In the semi field system, the ATSB significantly reduced a free-flying population of Ae. aegypti within 24 hours (incidence rate ratio (IRR) = 0.62; [95% confidence interval (95%CI); 0.54-0.70] and p-value < 0.001). However, in the field, the ATSBs required the addition of yeast as a carbon dioxide source to efficiently attract Ae. aegypti mosquitoes to feed. Conclusion Ivermectin is an active ingredient that can be used in an ATSB for Ae. aegypti depopulation. However, further research is needed to improve the developed and tested ATSB to compete with natural sources of sugar in a natural environment. F1000 Research Limited 2022-01-05 /pmc/articles/PMC10318376/ /pubmed/37409221 http://dx.doi.org/10.12688/wellcomeopenres.17442.1 Text en Copyright: © 2022 Tenywa FSC et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Tenywa, Frank Sandra Chelestino Musa, Jeremiah John Musiba, Revocatus Musyangi Swai, Johnson Kyeba Mpelepele, Ahmad Bakar Okumu, Fredros Okech Maia, Marta Ferreira Evaluation of an ivermectin-based attractive targeted sugar bait (ATSB) against Aedes aegypti in Tanzania. |
title | Evaluation of an ivermectin-based attractive targeted sugar bait (ATSB) against
Aedes aegypti in Tanzania. |
title_full | Evaluation of an ivermectin-based attractive targeted sugar bait (ATSB) against
Aedes aegypti in Tanzania. |
title_fullStr | Evaluation of an ivermectin-based attractive targeted sugar bait (ATSB) against
Aedes aegypti in Tanzania. |
title_full_unstemmed | Evaluation of an ivermectin-based attractive targeted sugar bait (ATSB) against
Aedes aegypti in Tanzania. |
title_short | Evaluation of an ivermectin-based attractive targeted sugar bait (ATSB) against
Aedes aegypti in Tanzania. |
title_sort | evaluation of an ivermectin-based attractive targeted sugar bait (atsb) against
aedes aegypti in tanzania. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318376/ https://www.ncbi.nlm.nih.gov/pubmed/37409221 http://dx.doi.org/10.12688/wellcomeopenres.17442.1 |
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