Cardiomyocyte-specific PCSK9 deficiency compromises mitochondrial bioenergetics and heart function

AIMS: Pro-protein convertase subtilisin-kexin type 9 (PCSK9), which is expressed mainly in the liver and at low levels in the heart, regulates cholesterol levels by directing low-density lipoprotein receptors to degradation. Studies to determine the role of PCSK9 in the heart are complicated by the...

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Detalles Bibliográficos
Autores principales: Laudette, Marion, Lindbom, Malin, Arif, Muhammad, Cinato, Mathieu, Ruiz, Mario, Doran, Stephen, Miljanovic, Azra, Rutberg, Mikael, Andersson, Linda, Klevstig, Martina, Henricsson, Marcus, Bergh, Per-Olof, Bollano, Entela, Aung, Nay, Gustav Smith, J, Pilon, Marc, Hyötyläinen, Tuulia, Orešič, Matej, Perkins, Rosie, Mardinoglu, Adil, Levin, Malin C, Borén, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318396/
https://www.ncbi.nlm.nih.gov/pubmed/36880401
http://dx.doi.org/10.1093/cvr/cvad041

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