Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor

The calmodulin-activated α-kinase, eukaryotic elongation factor 2 kinase (eEF-2K), serves as a master regulator of translational elongation by specifically phosphorylating and reducing the ribosome affinity of the guanosine triphosphatase, eukaryotic elongation factor 2 (eEF-2). Given its critical r...

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Detalles Bibliográficos
Autores principales: Piserchio, Andrea, Isiorho, Eta A., Dalby, Kevin N., Ghose, Ranajeet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
JBC Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318512/
https://www.ncbi.nlm.nih.gov/pubmed/37172726
http://dx.doi.org/10.1016/j.jbc.2023.104813

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