Structural changes in NOTCH3 induced by CADASIL mutations: Role of cysteine and non-cysteine alterations

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a cerebral small vessel disease that results from mutations in NOTCH3. How mutations in NOTCH3 ultimately result in disease is not clear, although there is a predilection for mutations to alter th...

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Detalles Bibliográficos
Autores principales: Lee, Soo Jung, Zhang, Xiaojie, Wu, Emily, Sukpraphrute, Richard, Sukpraphrute, Catherine, Ye, Andrew, Wang, Michael M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318516/
https://www.ncbi.nlm.nih.gov/pubmed/37209821
http://dx.doi.org/10.1016/j.jbc.2023.104838

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