Reduced APPL1 impairs osteogenic differentiation of mesenchymal stem cells by facilitating MGP expression to disrupt the BMP2 pathway in osteoporosis

An imbalance of human mesenchymal stem cells (MSCs) adipogenic and osteogenic differentiation plays an important role in the pathogenesis of osteoporosis. Our previous study verified that Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1)/myoferlin deficiency pr...

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Detalles Bibliográficos
Autores principales: Yuan, Weiquan, Liu, Wenjie, Zhang, Yunhui, Wang, Xinglang, Xu, Chenhao, Li, Quanfeng, Ji, Pengfei, Wang, Jiaxin, Feng, Pei, Wu, Yanfeng, Shen, Huiyong, Wang, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318529/
https://www.ncbi.nlm.nih.gov/pubmed/37187293
http://dx.doi.org/10.1016/j.jbc.2023.104823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318529/
https://www.ncbi.nlm.nih.gov/pubmed/37187293
http://dx.doi.org/10.1016/j.jbc.2023.104823

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