Cargando…

Reduced APPL1 impairs osteogenic differentiation of mesenchymal stem cells by facilitating MGP expression to disrupt the BMP2 pathway in osteoporosis

An imbalance of human mesenchymal stem cells (MSCs) adipogenic and osteogenic differentiation plays an important role in the pathogenesis of osteoporosis. Our previous study verified that Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1)/myoferlin deficiency pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yuan, Weiquan, Liu, Wenjie, Zhang, Yunhui, Wang, Xinglang, Xu, Chenhao, Li, Quanfeng, Ji, Pengfei, Wang, Jiaxin, Feng, Pei, Wu, Yanfeng, Shen, Huiyong, Wang, Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318529/ https://www.ncbi.nlm.nih.gov/pubmed/37187293 http://dx.doi.org/10.1016/j.jbc.2023.104823

Ejemplares similares

Impairment of APPL1/Myoferlin facilitates adipogenic differentiation of mesenchymal stem cells by blocking autophagy flux in osteoporosis
por: Zhang, Yunhui, et al.
Publicado: (2022)

Association of Genetic Polymorphisms in the Matrix Gla Protein (MGP) Gene with Coronary Artery Disease and Serum MGP Levels
por: Karsli-Ceppioglu, S, et al.
Publicado: (2019)

Polymorphisms in MGP gene and their association with lead toxicity
por: Shaik, Abjal Pasha, et al.
Publicado: (2009)

Dp-ucMGP as a Biomarker in Sarcopenia
por: Schweighofer, Natascha, et al.
Publicado: (2022)

Identification of the effector domain of biglycan that facilitates BMP-2 osteogenic function
por: Jongwattanapisan, Prapaporn, et al.
Publicado: (2018)

Alpinetin alleviates osteoporosis by promoting osteogenic differentiation in BMSCs by triggering autophagy via PKA/mTOR/ULK1 signaling
por: Zeng, Chenying, et al.
Publicado: (2022)

Generation of a Matrix Gla (Mgp) floxed mouse, followed by conditional knockout, uncovers a new Mgp function in the eye
por: Borrás, Teresa, et al.
Publicado: (2020)

Sequence variation and immunogenicity of the Mycoplasma genitalium MgpB and MgpC adherence proteins during persistent infection of men with non-gonococcal urethritis
por: Wood, Gwendolyn E., et al.
Publicado: (2020)

CNN-MGP: Convolutional Neural Networks for Metagenomics Gene Prediction
por: Al-Ajlan, Amani, et al.
Publicado: (2018)

Hedgehog signaling is involved in the BMP9-induced osteogenic differentiation of mesenchymal stem cells
por: Li, Li, et al.
Publicado: (2023)

MGP Regulates Perivascular Adipose-Derived Stem Cells Differentiation Toward Smooth Muscle Cells Via BMP2/SMAD Pathway Enhancing Neointimal Formation
por: Ni, Hui, et al.
Publicado: (2022)

IRF2‐mediated upregulation of lncRNA HHAS1 facilitates the osteogenic differentiation of bone marrow‐derived mesenchymal stem cells by acting as a competing endogenous RNA
por: Ye, Guiwen, et al.
Publicado: (2021)

No association between MGP rs1800802 polymorphism and stenosis of the coronary artery
por: Roustazadeh, Abazar, et al.
Publicado: (2013)

The Role of GRP and MGP in the Development of Non-Hemorrhagic VKCFD1 Phenotypes
por: Ghosh, Suvoshree, et al.
Publicado: (2022)

The Active Isoforms of MGP Are Expressed in Healthy and Varicose Veins without Calcification
por: Gheorghe, Simona R., et al.
Publicado: (2021)

MGP-AttTCN: An interpretable machine learning model for the prediction of sepsis
por: Rosnati, Margherita, et al.
Publicado: (2021)

DEPTOR regulates osteogenic differentiation via inhibiting MEG3-mediated activation of BMP4 signaling and is involved in osteoporosis
por: Chen, Si, et al.
Publicado: (2018)

Mmu-miR-185 depletion promotes osteogenic differentiation and suppresses bone loss in osteoporosis through the Bgn-mediated BMP/Smad pathway
por: Cui, Qi, et al.
Publicado: (2019)

Matrix gla protein (MGP): an overexpressed and migration-promoting mesenchymal component in glioblastoma
por: Mertsch, Sonja, et al.
Publicado: (2009)

A Naturally Fluorescent Mgp Transgenic Mouse for Angiogenesis and Glaucoma Longitudinal Studies
por: Asokan, Priyadarsini, et al.
Publicado: (2018)

SNP haplotyping technique for evaluation of MGP 5′ UTR power in osteoblast cells
por: Roustazadeh, Abazar, et al.
Publicado: (2016)

Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities
por: Berasi, Stephen P, et al.
Publicado: (2011)

“Occurrence of bla(CTX-MGp1) and bla(CTX-MGp26) in third generation cephalosporin-resistant and carbapenem- resistant bacterial isolates from southwest region of Saudi Arabia-a preliminary study”
por: Sobia, Farrukh, et al.
Publicado: (2021)

Sustained Release of BMP-2 in Bioprinted Alginate for Osteogenicity in Mice and Rats
por: Poldervaart, Michelle T., et al.
Publicado: (2013)

Expression analysis of the osteoarthritis genetic susceptibility mapping to the matrix Gla protein gene MGP
por: Shepherd, Colin, et al.
Publicado: (2019)

Specific heterozygous variants in MGP lead to endoplasmic reticulum stress and cause spondyloepiphyseal dysplasia
por: Gourgas, Ophélie, et al.
Publicado: (2023)

The Osteogenic Study of Tissue Engineering Bone with BMP2 and BMP7 Gene-Modified Rat Adipose-Derived Stem Cell
por: Qing, Wang, et al.
Publicado: (2012)

Interleukin-6/interleukin-6 receptor complex promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells
por: Xie, Zhongyu, et al.
Publicado: (2018)

Attenuation of Chondrogenic Transformation in Vascular Smooth Muscle by Dietary Quercetin in the MGP-Deficient Mouse Model
por: Beazley, Kelly E., et al.
Publicado: (2013)

Vitamin K2-Dependent GGCX and MGP Are Required for Homeostatic Calcium Regulation of Sperm Maturation
por: Ma, He, et al.
Publicado: (2019)

Ectopic transient overexpression of OCT-4 facilitates BMP4-induced osteogenic transdifferentiation of human umbilical vein endothelial cells
por: Kim, Seung Hyun L, et al.
Publicado: (2020)

Galangin mitigates glucocorticoid-induced osteoporosis by activating autophagy of BMSCs via triggering the PKA/CREB signaling pathway: Galangin mitigates glucocorticoid-induced osteoporosis
por: Zeng, Chenying, et al.
Publicado: (2023)

LncRNA‐OG Promotes the Osteogenic Differentiation of Bone Marrow‐Derived Mesenchymal Stem Cells Under the Regulation of hnRNPK
por: Tang, Su'an, et al.
Publicado: (2018)

The N(6)-methyladenosine demethylase ALKBH5 negatively regulates the osteogenic differentiation of mesenchymal stem cells through PRMT6
por: Li, Zhaofeng, et al.
Publicado: (2021)

Resveratrol Synergistically Promotes BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells
por: Wang, Yonghui, et al.
Publicado: (2022)

SIRT6 promotes osteogenic differentiation of mesenchymal stem cells through BMP signaling
por: Zhang, Ping, et al.
Publicado: (2017)

Sox9 Potentiates BMP2-Induced Chondrogenic Differentiation and Inhibits BMP2-Induced Osteogenic Differentiation
por: Liao, Junyi, et al.
Publicado: (2014)

Efficient autocrine and paracrine signaling explain the osteogenic superiority of transgenic BMP-2 over rhBMP-2
por: Atasoy-Zeybek, Aysegul, et al.
Publicado: (2023)

Activation of JNKs is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells
por: Zhao, Yan-fang, et al.
Publicado: (2013)

MGP Promotes Colon Cancer Proliferation by Activating the NF-κB Pathway through Upregulation of the Calcium Signaling Pathway
por: Li, Xueqing, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_fr4batbfdr0q9gv5e9r72lmtf8