Application of left ventricular endomyocardial biopsy in the diagnosis of mitochondrial cardiomyopathy: a case report

BACKGROUND: The clinical features of mitochondrial cardiomyopathy (MCM) are diverse. It can present as hypertrophic cardiomyopathy or dilated cardiomyopathy. The diagnosis of MCM is challenging and usually based on biopsy. CASE PRESENTATION: The 30-year-old man was admitted to hospital due to dyspne...

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Autores principales: Fang, Chuangsen, Lan, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318631/
https://www.ncbi.nlm.nih.gov/pubmed/37403033
http://dx.doi.org/10.1186/s12872-023-03373-x
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author Fang, Chuangsen
Lan, Ming
author_facet Fang, Chuangsen
Lan, Ming
author_sort Fang, Chuangsen
collection PubMed
description BACKGROUND: The clinical features of mitochondrial cardiomyopathy (MCM) are diverse. It can present as hypertrophic cardiomyopathy or dilated cardiomyopathy. The diagnosis of MCM is challenging and usually based on biopsy. CASE PRESENTATION: The 30-year-old man was admitted to hospital due to dyspnea for 1 month and edema of both lower extremities for 1 week. Echocardiography suggested a whole heart enlargement, a whole heart diminished function. Renal impairment and diabetes were observed. Coronary angiography showed single-vessel disease (90% stenosis in the ostium of a small marginal branch). Left ventricular endomyocardial biopsy was performed. CONCLUSION: Myocardial histopathology demonstrated a large number of abnormal mitochondrial accumulation, so the diagnosis was considered as mitochondrial cardiomyopathy.
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spelling pubmed-103186312023-07-05 Application of left ventricular endomyocardial biopsy in the diagnosis of mitochondrial cardiomyopathy: a case report Fang, Chuangsen Lan, Ming BMC Cardiovasc Disord Case Report BACKGROUND: The clinical features of mitochondrial cardiomyopathy (MCM) are diverse. It can present as hypertrophic cardiomyopathy or dilated cardiomyopathy. The diagnosis of MCM is challenging and usually based on biopsy. CASE PRESENTATION: The 30-year-old man was admitted to hospital due to dyspnea for 1 month and edema of both lower extremities for 1 week. Echocardiography suggested a whole heart enlargement, a whole heart diminished function. Renal impairment and diabetes were observed. Coronary angiography showed single-vessel disease (90% stenosis in the ostium of a small marginal branch). Left ventricular endomyocardial biopsy was performed. CONCLUSION: Myocardial histopathology demonstrated a large number of abnormal mitochondrial accumulation, so the diagnosis was considered as mitochondrial cardiomyopathy. BioMed Central 2023-07-04 /pmc/articles/PMC10318631/ /pubmed/37403033 http://dx.doi.org/10.1186/s12872-023-03373-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Fang, Chuangsen
Lan, Ming
Application of left ventricular endomyocardial biopsy in the diagnosis of mitochondrial cardiomyopathy: a case report
title Application of left ventricular endomyocardial biopsy in the diagnosis of mitochondrial cardiomyopathy: a case report
title_full Application of left ventricular endomyocardial biopsy in the diagnosis of mitochondrial cardiomyopathy: a case report
title_fullStr Application of left ventricular endomyocardial biopsy in the diagnosis of mitochondrial cardiomyopathy: a case report
title_full_unstemmed Application of left ventricular endomyocardial biopsy in the diagnosis of mitochondrial cardiomyopathy: a case report
title_short Application of left ventricular endomyocardial biopsy in the diagnosis of mitochondrial cardiomyopathy: a case report
title_sort application of left ventricular endomyocardial biopsy in the diagnosis of mitochondrial cardiomyopathy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318631/
https://www.ncbi.nlm.nih.gov/pubmed/37403033
http://dx.doi.org/10.1186/s12872-023-03373-x
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