ER Ca(2+) overload activates the IRE1α signaling and promotes cell survival

BACKGROUND: Maintaining homeostasis of Ca(2+) stores in the endoplasmic reticulum (ER) is crucial for proper Ca(2+) signaling and key cellular functions. Although Ca(2+) depletion has been known to cause ER stress which in turn activates the unfolded protein response (UPR), how UPR sensors/transduce...

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Detalles Bibliográficos
Autores principales: Zhao, Song, Feng, Haiping, Jiang, Dongfang, Yang, Keyan, Wang, Si-Tong, Zhang, Yu-Xin, Wang, Yun, Liu, Hongmei, Guo, Caixia, Tang, Tie-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318635/
https://www.ncbi.nlm.nih.gov/pubmed/37400935
http://dx.doi.org/10.1186/s13578-023-01062-y

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