Single-cell RNA sequencing for the study of kidney disease

The kidney is an important organ for maintaining normal metabolism and stabilising the internal environment, in which, the heterogeneity of cell types has hindered the progress in understanding the mechanisms underlying kidney disease. In recent years the application of single-cell RNA sequencing (s...

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Detalles Bibliográficos
Autores principales: Zhu, Jiayi, Lu, Jinrong, Weng, Huachun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318824/
https://www.ncbi.nlm.nih.gov/pubmed/37400792
http://dx.doi.org/10.1186/s10020-023-00693-8
Descripción
Sumario:The kidney is an important organ for maintaining normal metabolism and stabilising the internal environment, in which, the heterogeneity of cell types has hindered the progress in understanding the mechanisms underlying kidney disease. In recent years the application of single-cell RNA sequencing (scRNA-seq) in nephrology has developed rapidly. In this review, we summarized the technical platform related to scRNA-seq and the role of this technology in investigating the onset and development of kidney diseases, starting from several common kidney diseases (mainly including lupus nephritis, renal cell carcinoma, diabetic nephropathy and acute kidney injury), and provide a reference for the application of scRNA-seq in the study of kidney disease diagnosis, treatment and prognosis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s10020-023-00693-8.

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