Single-cell RNA sequencing for the study of kidney disease

The kidney is an important organ for maintaining normal metabolism and stabilising the internal environment, in which, the heterogeneity of cell types has hindered the progress in understanding the mechanisms underlying kidney disease. In recent years the application of single-cell RNA sequencing (s...

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Detalles Bibliográficos
Autores principales: Zhu, Jiayi, Lu, Jinrong, Weng, Huachun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318824/
https://www.ncbi.nlm.nih.gov/pubmed/37400792
http://dx.doi.org/10.1186/s10020-023-00693-8
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author Zhu, Jiayi
Lu, Jinrong
Weng, Huachun
author_facet Zhu, Jiayi
Lu, Jinrong
Weng, Huachun
author_sort Zhu, Jiayi
collection PubMed
description The kidney is an important organ for maintaining normal metabolism and stabilising the internal environment, in which, the heterogeneity of cell types has hindered the progress in understanding the mechanisms underlying kidney disease. In recent years the application of single-cell RNA sequencing (scRNA-seq) in nephrology has developed rapidly. In this review, we summarized the technical platform related to scRNA-seq and the role of this technology in investigating the onset and development of kidney diseases, starting from several common kidney diseases (mainly including lupus nephritis, renal cell carcinoma, diabetic nephropathy and acute kidney injury), and provide a reference for the application of scRNA-seq in the study of kidney disease diagnosis, treatment and prognosis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s10020-023-00693-8.
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spelling pubmed-103188242023-07-05 Single-cell RNA sequencing for the study of kidney disease Zhu, Jiayi Lu, Jinrong Weng, Huachun Mol Med Review The kidney is an important organ for maintaining normal metabolism and stabilising the internal environment, in which, the heterogeneity of cell types has hindered the progress in understanding the mechanisms underlying kidney disease. In recent years the application of single-cell RNA sequencing (scRNA-seq) in nephrology has developed rapidly. In this review, we summarized the technical platform related to scRNA-seq and the role of this technology in investigating the onset and development of kidney diseases, starting from several common kidney diseases (mainly including lupus nephritis, renal cell carcinoma, diabetic nephropathy and acute kidney injury), and provide a reference for the application of scRNA-seq in the study of kidney disease diagnosis, treatment and prognosis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s10020-023-00693-8. BioMed Central 2023-07-03 /pmc/articles/PMC10318824/ /pubmed/37400792 http://dx.doi.org/10.1186/s10020-023-00693-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Zhu, Jiayi
Lu, Jinrong
Weng, Huachun
Single-cell RNA sequencing for the study of kidney disease
title Single-cell RNA sequencing for the study of kidney disease
title_full Single-cell RNA sequencing for the study of kidney disease
title_fullStr Single-cell RNA sequencing for the study of kidney disease
title_full_unstemmed Single-cell RNA sequencing for the study of kidney disease
title_short Single-cell RNA sequencing for the study of kidney disease
title_sort single-cell rna sequencing for the study of kidney disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318824/
https://www.ncbi.nlm.nih.gov/pubmed/37400792
http://dx.doi.org/10.1186/s10020-023-00693-8
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