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Predisposition to soil-transmitted helminth reinfection after four rounds of mass drug administration: results from a longitudinal cohort in the Geshiyaro project, a transmission elimination feasibility study in the Wolaita zone of southern Ethiopia

BACKGROUND: Current WHO strategies for reaching soil-transmitted helminths (STH) elimination as a public health problem excludes treating certain adult populations in endemic areas, creating infection reservoirs that drive ‘bounce back’ of STH infection to pretreatment levels post-mass drug administ...

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Autores principales: Rayment Gomez, Santiago, Maddren, Rosie, Liyew, Ewnetu Firdawek, Chernet, Melkie, Anjulo, Ufaysa, Tamiru, Adugna, Mengitsu, Birhan, Forbes, Kathryn, Collyer, Benjamin, Salasibew, Mihretab, Anderson, Roy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318869/
https://www.ncbi.nlm.nih.gov/pubmed/36939014
http://dx.doi.org/10.1093/trstmh/trad007
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author Rayment Gomez, Santiago
Maddren, Rosie
Liyew, Ewnetu Firdawek
Chernet, Melkie
Anjulo, Ufaysa
Tamiru, Adugna
Mengitsu, Birhan
Forbes, Kathryn
Collyer, Benjamin
Salasibew, Mihretab
Anderson, Roy
author_facet Rayment Gomez, Santiago
Maddren, Rosie
Liyew, Ewnetu Firdawek
Chernet, Melkie
Anjulo, Ufaysa
Tamiru, Adugna
Mengitsu, Birhan
Forbes, Kathryn
Collyer, Benjamin
Salasibew, Mihretab
Anderson, Roy
author_sort Rayment Gomez, Santiago
collection PubMed
description BACKGROUND: Current WHO strategies for reaching soil-transmitted helminths (STH) elimination as a public health problem excludes treating certain adult populations in endemic areas, creating infection reservoirs that drive ‘bounce back’ of STH infection to pretreatment levels post-mass drug administration (MDA). Predisposition is a widespread, but poorly understood phenomena among helminth infections where individuals are predisposed to reinfection after repeated treatments. METHODS: This analysis uses Geshiyaro project data, an STH control programme exploring transmission interruption by community-wide MDA and enhanced water, sanitation and hygiene during 2019–2023. Parasitological survey data from longitudinal cohorts are analysed using Kendall's Tau-b rank correlation to assess the evidence for predisposition to light or heavy infection between four consecutive rounds of MDA. RESULTS: Correlation analyses revealed the strongest evidence for predisposition to heavy or light Ascaris lumbricoides infection was between survey 1 and 2 (Tau-b 0.29; p<0.001). Overall patterns were not observed for Trichuris trichiura or hookworm infections, however, some significant and notable correlations were recorded for some stratifications and time points. CONCLUSIONS: Evidence for predisposition in endemic settings in southern Ethiopia with low STH prevalence suggests that more targeted approaches to MDA in those predisposed to infection may be a sensible control strategy if cheap, point of care diagnostics are available.
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spelling pubmed-103188692023-07-05 Predisposition to soil-transmitted helminth reinfection after four rounds of mass drug administration: results from a longitudinal cohort in the Geshiyaro project, a transmission elimination feasibility study in the Wolaita zone of southern Ethiopia Rayment Gomez, Santiago Maddren, Rosie Liyew, Ewnetu Firdawek Chernet, Melkie Anjulo, Ufaysa Tamiru, Adugna Mengitsu, Birhan Forbes, Kathryn Collyer, Benjamin Salasibew, Mihretab Anderson, Roy Trans R Soc Trop Med Hyg Original Article BACKGROUND: Current WHO strategies for reaching soil-transmitted helminths (STH) elimination as a public health problem excludes treating certain adult populations in endemic areas, creating infection reservoirs that drive ‘bounce back’ of STH infection to pretreatment levels post-mass drug administration (MDA). Predisposition is a widespread, but poorly understood phenomena among helminth infections where individuals are predisposed to reinfection after repeated treatments. METHODS: This analysis uses Geshiyaro project data, an STH control programme exploring transmission interruption by community-wide MDA and enhanced water, sanitation and hygiene during 2019–2023. Parasitological survey data from longitudinal cohorts are analysed using Kendall's Tau-b rank correlation to assess the evidence for predisposition to light or heavy infection between four consecutive rounds of MDA. RESULTS: Correlation analyses revealed the strongest evidence for predisposition to heavy or light Ascaris lumbricoides infection was between survey 1 and 2 (Tau-b 0.29; p<0.001). Overall patterns were not observed for Trichuris trichiura or hookworm infections, however, some significant and notable correlations were recorded for some stratifications and time points. CONCLUSIONS: Evidence for predisposition in endemic settings in southern Ethiopia with low STH prevalence suggests that more targeted approaches to MDA in those predisposed to infection may be a sensible control strategy if cheap, point of care diagnostics are available. Oxford University Press 2023-03-20 /pmc/articles/PMC10318869/ /pubmed/36939014 http://dx.doi.org/10.1093/trstmh/trad007 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Article
Rayment Gomez, Santiago
Maddren, Rosie
Liyew, Ewnetu Firdawek
Chernet, Melkie
Anjulo, Ufaysa
Tamiru, Adugna
Mengitsu, Birhan
Forbes, Kathryn
Collyer, Benjamin
Salasibew, Mihretab
Anderson, Roy
Predisposition to soil-transmitted helminth reinfection after four rounds of mass drug administration: results from a longitudinal cohort in the Geshiyaro project, a transmission elimination feasibility study in the Wolaita zone of southern Ethiopia
title Predisposition to soil-transmitted helminth reinfection after four rounds of mass drug administration: results from a longitudinal cohort in the Geshiyaro project, a transmission elimination feasibility study in the Wolaita zone of southern Ethiopia
title_full Predisposition to soil-transmitted helminth reinfection after four rounds of mass drug administration: results from a longitudinal cohort in the Geshiyaro project, a transmission elimination feasibility study in the Wolaita zone of southern Ethiopia
title_fullStr Predisposition to soil-transmitted helminth reinfection after four rounds of mass drug administration: results from a longitudinal cohort in the Geshiyaro project, a transmission elimination feasibility study in the Wolaita zone of southern Ethiopia
title_full_unstemmed Predisposition to soil-transmitted helminth reinfection after four rounds of mass drug administration: results from a longitudinal cohort in the Geshiyaro project, a transmission elimination feasibility study in the Wolaita zone of southern Ethiopia
title_short Predisposition to soil-transmitted helminth reinfection after four rounds of mass drug administration: results from a longitudinal cohort in the Geshiyaro project, a transmission elimination feasibility study in the Wolaita zone of southern Ethiopia
title_sort predisposition to soil-transmitted helminth reinfection after four rounds of mass drug administration: results from a longitudinal cohort in the geshiyaro project, a transmission elimination feasibility study in the wolaita zone of southern ethiopia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318869/
https://www.ncbi.nlm.nih.gov/pubmed/36939014
http://dx.doi.org/10.1093/trstmh/trad007
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