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WHO should accelerate, not stall, rectal artesunate deployment for pre-referral treatment of severe malaria
The recent World Health Organization moratorium on rectal artesunate (RAS) for pre-referral treatment of severe childhood malaria is costing young lives. The decision was based on disappointing findings from a large observational study that provided RAS to community health workers with little traini...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318884/ https://www.ncbi.nlm.nih.gov/pubmed/36722432 http://dx.doi.org/10.1093/trstmh/trad002 |
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author | Peto, Thomas J Watson, James A White, Nicholas J Dondorp, Arjen M |
author_facet | Peto, Thomas J Watson, James A White, Nicholas J Dondorp, Arjen M |
author_sort | Peto, Thomas J |
collection | PubMed |
description | The recent World Health Organization moratorium on rectal artesunate (RAS) for pre-referral treatment of severe childhood malaria is costing young lives. The decision was based on disappointing findings from a large observational study that provided RAS to community health workers with little training and supervision. This non-randomized, operational research has provided useful information to guide the implementation of RAS but is subject to bias and confounding and cannot be used to assess treatment effects. Parenteral artesunate reduces severe malaria mortality and a large body of evidence also shows RAS has lifesaving efficacy. There is now more than a decade of delay in conducting the necessary engagement and training required for successful deployment of RAS. Further delays will result in more preventable deaths. |
format | Online Article Text |
id | pubmed-10318884 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-103188842023-07-05 WHO should accelerate, not stall, rectal artesunate deployment for pre-referral treatment of severe malaria Peto, Thomas J Watson, James A White, Nicholas J Dondorp, Arjen M Trans R Soc Trop Med Hyg Commentary The recent World Health Organization moratorium on rectal artesunate (RAS) for pre-referral treatment of severe childhood malaria is costing young lives. The decision was based on disappointing findings from a large observational study that provided RAS to community health workers with little training and supervision. This non-randomized, operational research has provided useful information to guide the implementation of RAS but is subject to bias and confounding and cannot be used to assess treatment effects. Parenteral artesunate reduces severe malaria mortality and a large body of evidence also shows RAS has lifesaving efficacy. There is now more than a decade of delay in conducting the necessary engagement and training required for successful deployment of RAS. Further delays will result in more preventable deaths. Oxford University Press 2023-02-01 /pmc/articles/PMC10318884/ /pubmed/36722432 http://dx.doi.org/10.1093/trstmh/trad002 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Commentary Peto, Thomas J Watson, James A White, Nicholas J Dondorp, Arjen M WHO should accelerate, not stall, rectal artesunate deployment for pre-referral treatment of severe malaria |
title | WHO should accelerate, not stall, rectal artesunate deployment for pre-referral treatment of severe malaria |
title_full | WHO should accelerate, not stall, rectal artesunate deployment for pre-referral treatment of severe malaria |
title_fullStr | WHO should accelerate, not stall, rectal artesunate deployment for pre-referral treatment of severe malaria |
title_full_unstemmed | WHO should accelerate, not stall, rectal artesunate deployment for pre-referral treatment of severe malaria |
title_short | WHO should accelerate, not stall, rectal artesunate deployment for pre-referral treatment of severe malaria |
title_sort | who should accelerate, not stall, rectal artesunate deployment for pre-referral treatment of severe malaria |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318884/ https://www.ncbi.nlm.nih.gov/pubmed/36722432 http://dx.doi.org/10.1093/trstmh/trad002 |
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