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Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis

BACKGROUND: Previous epidemiological observational studies have reported an association between inflammatory bowel disease (IBD) and prostate cancer (PCa), but the causality is inconclusive. The purpose of this study was to evaluate the causality of IBD on PCa using the mendelian randomization (MR)...

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Autores principales: Cheng, Wen, Liao, Yang, Mou, Ruiyu, Xiao, Xian, Jia, Yingjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318899/
https://www.ncbi.nlm.nih.gov/pubmed/37409117
http://dx.doi.org/10.3389/fimmu.2023.1157313
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author Cheng, Wen
Liao, Yang
Mou, Ruiyu
Xiao, Xian
Jia, Yingjie
author_facet Cheng, Wen
Liao, Yang
Mou, Ruiyu
Xiao, Xian
Jia, Yingjie
author_sort Cheng, Wen
collection PubMed
description BACKGROUND: Previous epidemiological observational studies have reported an association between inflammatory bowel disease (IBD) and prostate cancer (PCa), but the causality is inconclusive. The purpose of this study was to evaluate the causality of IBD on PCa using the mendelian randomization (MR) analysis. METHODS: We performed a two-sample MR analysis with public genome-wide association studies (GWAS) data. Eligible instrumental variables (IVs) were selected according to the three assumptions of MR analysis. The inverse-variance weighted (IVW) method was the main method. Complementary methods included the MR-Egger regression, the Weighted Median, the Simple Mode, the Weighted Mode and MR pleiotropy residual sum and outlier (MR-PRESSO) methods. RESULTS: Genetically determined IBD did not have a causal effect on PCa (IVW P > 0.05). Additionally, there was no causal effect of Crohn’s disease (CD) and ulcerative colitis (UC) on PCa in the MR analysis (IVW P > 0.05). Results of complementary methods were consistent with those of the IVW method. CONCLUSIONS: This study does not support a causal association of IBD on PCa, which is in contrast to most observational studies.
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spelling pubmed-103188992023-07-05 Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis Cheng, Wen Liao, Yang Mou, Ruiyu Xiao, Xian Jia, Yingjie Front Immunol Immunology BACKGROUND: Previous epidemiological observational studies have reported an association between inflammatory bowel disease (IBD) and prostate cancer (PCa), but the causality is inconclusive. The purpose of this study was to evaluate the causality of IBD on PCa using the mendelian randomization (MR) analysis. METHODS: We performed a two-sample MR analysis with public genome-wide association studies (GWAS) data. Eligible instrumental variables (IVs) were selected according to the three assumptions of MR analysis. The inverse-variance weighted (IVW) method was the main method. Complementary methods included the MR-Egger regression, the Weighted Median, the Simple Mode, the Weighted Mode and MR pleiotropy residual sum and outlier (MR-PRESSO) methods. RESULTS: Genetically determined IBD did not have a causal effect on PCa (IVW P > 0.05). Additionally, there was no causal effect of Crohn’s disease (CD) and ulcerative colitis (UC) on PCa in the MR analysis (IVW P > 0.05). Results of complementary methods were consistent with those of the IVW method. CONCLUSIONS: This study does not support a causal association of IBD on PCa, which is in contrast to most observational studies. Frontiers Media S.A. 2023-06-20 /pmc/articles/PMC10318899/ /pubmed/37409117 http://dx.doi.org/10.3389/fimmu.2023.1157313 Text en Copyright © 2023 Cheng, Liao, Mou, Xiao and Jia https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Cheng, Wen
Liao, Yang
Mou, Ruiyu
Xiao, Xian
Jia, Yingjie
Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis
title Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis
title_full Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis
title_fullStr Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis
title_full_unstemmed Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis
title_short Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis
title_sort inflammatory bowel disease and prostate cancer risk: a two-sample mendelian randomization analysis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318899/
https://www.ncbi.nlm.nih.gov/pubmed/37409117
http://dx.doi.org/10.3389/fimmu.2023.1157313
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