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Total serum FGF-21 levels positively relate to visceral adiposity differently from its functional intact form

OBJECTIVE: Increased Fibroblast Growth Factor-21 (FGF-21) circulating levels have been described in obesity. In this observational study, we analysed a group of subjects with metabolic disorders to unravel the putative link between visceral adiposity and FGF-21 serum levels. METHODS: Total and intac...

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Autores principales: Crudele, Lucilla, Garcia-Irigoyen, Oihane, Cariello, Marica, Piglionica, Marilidia, Scialpi, Natasha, Florio, Marilina, Piazzolla, Giuseppina, Suppressa, Patrizia, Sabbà, Carlo, Gadaleta, Raffaella Maria, Moschetta, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319105/
https://www.ncbi.nlm.nih.gov/pubmed/37409233
http://dx.doi.org/10.3389/fendo.2023.1159127
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author Crudele, Lucilla
Garcia-Irigoyen, Oihane
Cariello, Marica
Piglionica, Marilidia
Scialpi, Natasha
Florio, Marilina
Piazzolla, Giuseppina
Suppressa, Patrizia
Sabbà, Carlo
Gadaleta, Raffaella Maria
Moschetta, Antonio
author_facet Crudele, Lucilla
Garcia-Irigoyen, Oihane
Cariello, Marica
Piglionica, Marilidia
Scialpi, Natasha
Florio, Marilina
Piazzolla, Giuseppina
Suppressa, Patrizia
Sabbà, Carlo
Gadaleta, Raffaella Maria
Moschetta, Antonio
author_sort Crudele, Lucilla
collection PubMed
description OBJECTIVE: Increased Fibroblast Growth Factor-21 (FGF-21) circulating levels have been described in obesity. In this observational study, we analysed a group of subjects with metabolic disorders to unravel the putative link between visceral adiposity and FGF-21 serum levels. METHODS: Total and intact serum FGF-21 concentration was measured with an ELISA assay respectively in 51 and 46 subjects, comparing FGF-21 levels in dysmetabolic conditions. We also tested Spearman’s correlations between FGF-21 serum levels and biochemical and clinical metabolic parameters. RESULTS: FGF-21 was not significantly increased in high-risk conditions such as visceral obesity, Metabolic Syndrome, diabetes, smoking, and atherosclerosis. Waist Circumference (WC), but not BMI, positively correlated with total FGF-21 levels (r=0.31, p <0.05), while HDL-cholesterol (r=-0.29, p <0.05) and 25-OH Vitamin D (r=-0.32, p <0.05) showed a significant negative correlation with total FGF-21. ROC analysis of FGF-21 in prediction of increased WC, showed that patients with total FGF-21 level over cut-off value of 161.47 pg/mL presented with impaired FPG. Conversely, serum levels of the intact form of FGF-21 did not correlate with WC and other metabolic biomarkers. CONCLUSION: Our newly calculated cut-off for total FGF-21 according to visceral adiposity identified subjects with fasting hyperglycemia. However, waist circumference correlates with total FGF-21 serum levels but does not correlate with intact FGF-21, suggesting that functional FGF-21 does not necessarily relate with obesity and metabolic features.
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spelling pubmed-103191052023-07-05 Total serum FGF-21 levels positively relate to visceral adiposity differently from its functional intact form Crudele, Lucilla Garcia-Irigoyen, Oihane Cariello, Marica Piglionica, Marilidia Scialpi, Natasha Florio, Marilina Piazzolla, Giuseppina Suppressa, Patrizia Sabbà, Carlo Gadaleta, Raffaella Maria Moschetta, Antonio Front Endocrinol (Lausanne) Endocrinology OBJECTIVE: Increased Fibroblast Growth Factor-21 (FGF-21) circulating levels have been described in obesity. In this observational study, we analysed a group of subjects with metabolic disorders to unravel the putative link between visceral adiposity and FGF-21 serum levels. METHODS: Total and intact serum FGF-21 concentration was measured with an ELISA assay respectively in 51 and 46 subjects, comparing FGF-21 levels in dysmetabolic conditions. We also tested Spearman’s correlations between FGF-21 serum levels and biochemical and clinical metabolic parameters. RESULTS: FGF-21 was not significantly increased in high-risk conditions such as visceral obesity, Metabolic Syndrome, diabetes, smoking, and atherosclerosis. Waist Circumference (WC), but not BMI, positively correlated with total FGF-21 levels (r=0.31, p <0.05), while HDL-cholesterol (r=-0.29, p <0.05) and 25-OH Vitamin D (r=-0.32, p <0.05) showed a significant negative correlation with total FGF-21. ROC analysis of FGF-21 in prediction of increased WC, showed that patients with total FGF-21 level over cut-off value of 161.47 pg/mL presented with impaired FPG. Conversely, serum levels of the intact form of FGF-21 did not correlate with WC and other metabolic biomarkers. CONCLUSION: Our newly calculated cut-off for total FGF-21 according to visceral adiposity identified subjects with fasting hyperglycemia. However, waist circumference correlates with total FGF-21 serum levels but does not correlate with intact FGF-21, suggesting that functional FGF-21 does not necessarily relate with obesity and metabolic features. Frontiers Media S.A. 2023-06-20 /pmc/articles/PMC10319105/ /pubmed/37409233 http://dx.doi.org/10.3389/fendo.2023.1159127 Text en Copyright © 2023 Crudele, Garcia-Irigoyen, Cariello, Piglionica, Scialpi, Florio, Piazzolla, Suppressa, Sabbà, Gadaleta and Moschetta https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Crudele, Lucilla
Garcia-Irigoyen, Oihane
Cariello, Marica
Piglionica, Marilidia
Scialpi, Natasha
Florio, Marilina
Piazzolla, Giuseppina
Suppressa, Patrizia
Sabbà, Carlo
Gadaleta, Raffaella Maria
Moschetta, Antonio
Total serum FGF-21 levels positively relate to visceral adiposity differently from its functional intact form
title Total serum FGF-21 levels positively relate to visceral adiposity differently from its functional intact form
title_full Total serum FGF-21 levels positively relate to visceral adiposity differently from its functional intact form
title_fullStr Total serum FGF-21 levels positively relate to visceral adiposity differently from its functional intact form
title_full_unstemmed Total serum FGF-21 levels positively relate to visceral adiposity differently from its functional intact form
title_short Total serum FGF-21 levels positively relate to visceral adiposity differently from its functional intact form
title_sort total serum fgf-21 levels positively relate to visceral adiposity differently from its functional intact form
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319105/
https://www.ncbi.nlm.nih.gov/pubmed/37409233
http://dx.doi.org/10.3389/fendo.2023.1159127
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