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OVX033, a nucleocapsid-based vaccine candidate, provides broad-spectrum protection against SARS-CoV-2 variants in a hamster challenge model
Spike-based COVID-19 vaccines induce potent neutralizing antibodies but their efficacy against SARS-CoV-2 variants decreases. OVX033 is a recombinant protein composed of the full-length nucleocapsid (N) protein of SARS-CoV-2 genetically fused to oligoDOM(®), a self-assembling domain which improves a...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319154/ https://www.ncbi.nlm.nih.gov/pubmed/37409116 http://dx.doi.org/10.3389/fimmu.2023.1188605 |
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| author | Primard, Charlotte Monchâtre-Leroy, Elodie Del Campo, Judith Valsesia, Séverine Nikly, Elsa Chevandier, Marion Boué, Franck Servat, Alexandre Wasniewski, Marine Picard-Meyer, Evelyne Courant, Thomas Collin, Nicolas Salguero, Francisco J. Le Vert, Alexandre Guyon-Gellin, Delphine Nicolas, Florence |
| author_facet | Primard, Charlotte Monchâtre-Leroy, Elodie Del Campo, Judith Valsesia, Séverine Nikly, Elsa Chevandier, Marion Boué, Franck Servat, Alexandre Wasniewski, Marine Picard-Meyer, Evelyne Courant, Thomas Collin, Nicolas Salguero, Francisco J. Le Vert, Alexandre Guyon-Gellin, Delphine Nicolas, Florence |
| author_sort | Primard, Charlotte |
| collection | PubMed |
| description | Spike-based COVID-19 vaccines induce potent neutralizing antibodies but their efficacy against SARS-CoV-2 variants decreases. OVX033 is a recombinant protein composed of the full-length nucleocapsid (N) protein of SARS-CoV-2 genetically fused to oligoDOM(®), a self-assembling domain which improves antigen immunogenicity. OVX033 including N as an antigenic target is proposed as new vaccine candidate providing broad-spectrum protection against sarbecoviruses. OVX033 demonstrated its ability to trigger cross-reactive T cell responses and cross-protection against three variants of SARS-CoV-2 (B.1 Europe, Delta B.1.617.2, and Omicron B.1.1.529) in a hamster challenge model, as evidenced by lower weight loss, lower lung viral loads, and reduced lung histopathological lesions. |
| format | Online Article Text |
| id | pubmed-10319154 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Frontiers Media S.A. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-103191542023-07-05 OVX033, a nucleocapsid-based vaccine candidate, provides broad-spectrum protection against SARS-CoV-2 variants in a hamster challenge model Primard, Charlotte Monchâtre-Leroy, Elodie Del Campo, Judith Valsesia, Séverine Nikly, Elsa Chevandier, Marion Boué, Franck Servat, Alexandre Wasniewski, Marine Picard-Meyer, Evelyne Courant, Thomas Collin, Nicolas Salguero, Francisco J. Le Vert, Alexandre Guyon-Gellin, Delphine Nicolas, Florence Front Immunol Immunology Spike-based COVID-19 vaccines induce potent neutralizing antibodies but their efficacy against SARS-CoV-2 variants decreases. OVX033 is a recombinant protein composed of the full-length nucleocapsid (N) protein of SARS-CoV-2 genetically fused to oligoDOM(®), a self-assembling domain which improves antigen immunogenicity. OVX033 including N as an antigenic target is proposed as new vaccine candidate providing broad-spectrum protection against sarbecoviruses. OVX033 demonstrated its ability to trigger cross-reactive T cell responses and cross-protection against three variants of SARS-CoV-2 (B.1 Europe, Delta B.1.617.2, and Omicron B.1.1.529) in a hamster challenge model, as evidenced by lower weight loss, lower lung viral loads, and reduced lung histopathological lesions. Frontiers Media S.A. 2023-06-19 /pmc/articles/PMC10319154/ /pubmed/37409116 http://dx.doi.org/10.3389/fimmu.2023.1188605 Text en Copyright © 2023 Primard, Monchâtre-Leroy, Del Campo, Valsesia, Nikly, Chevandier, Boué, Servat, Wasniewski, Picard-Meyer, Courant, Collin, Salguero, Le Vert, Guyon-Gellin and Nicolas https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| spellingShingle | Immunology Primard, Charlotte Monchâtre-Leroy, Elodie Del Campo, Judith Valsesia, Séverine Nikly, Elsa Chevandier, Marion Boué, Franck Servat, Alexandre Wasniewski, Marine Picard-Meyer, Evelyne Courant, Thomas Collin, Nicolas Salguero, Francisco J. Le Vert, Alexandre Guyon-Gellin, Delphine Nicolas, Florence OVX033, a nucleocapsid-based vaccine candidate, provides broad-spectrum protection against SARS-CoV-2 variants in a hamster challenge model |
| title | OVX033, a nucleocapsid-based vaccine candidate, provides broad-spectrum protection against SARS-CoV-2 variants in a hamster challenge model |
| title_full | OVX033, a nucleocapsid-based vaccine candidate, provides broad-spectrum protection against SARS-CoV-2 variants in a hamster challenge model |
| title_fullStr | OVX033, a nucleocapsid-based vaccine candidate, provides broad-spectrum protection against SARS-CoV-2 variants in a hamster challenge model |
| title_full_unstemmed | OVX033, a nucleocapsid-based vaccine candidate, provides broad-spectrum protection against SARS-CoV-2 variants in a hamster challenge model |
| title_short | OVX033, a nucleocapsid-based vaccine candidate, provides broad-spectrum protection against SARS-CoV-2 variants in a hamster challenge model |
| title_sort | ovx033, a nucleocapsid-based vaccine candidate, provides broad-spectrum protection against sars-cov-2 variants in a hamster challenge model |
| topic | Immunology |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319154/ https://www.ncbi.nlm.nih.gov/pubmed/37409116 http://dx.doi.org/10.3389/fimmu.2023.1188605 |
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