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Serum Vitamin D Levels in Pediatric Tuberculosis Patients in a Tertiary Care Center in India: A Case-Control Study

Background Mycobacterium is certainly one individual organism contributing to the most deaths of children among the world’s lower- and medium-income nations. According to earlier studies, vitamin D insufficiency is one of the risk factors. We undertook this study since very few case-control studies...

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Autores principales: Ageeru, Karthik, Mendu, Suresh Babu, Avinash, Santhosh, Kalyani, Srinivasa, Kotha, Rakesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319357/
https://www.ncbi.nlm.nih.gov/pubmed/37409212
http://dx.doi.org/10.7759/cureus.39937
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author Ageeru, Karthik
Mendu, Suresh Babu
Avinash, Santhosh
Kalyani, Srinivasa
Kotha, Rakesh
author_facet Ageeru, Karthik
Mendu, Suresh Babu
Avinash, Santhosh
Kalyani, Srinivasa
Kotha, Rakesh
author_sort Ageeru, Karthik
collection PubMed
description Background Mycobacterium is certainly one individual organism contributing to the most deaths of children among the world’s lower- and medium-income nations. According to earlier studies, vitamin D insufficiency is one of the risk factors. We undertook this study since very few case-control studies are present. This study aimed to evaluate the role of vitamin D in tuberculosis (TB). Methods This case-control study was carried out in a tertiary care center at Niloufer Hospital over a period of one year and five months. The sample size was 140. SPSS (Statistical Package for the Social Sciences) Version 19 (IBM Corp., Armonk, NY) was used for statistical analysis. Two-tailed p-values and odds ratios were obtained. The chi-square test was applied to differentiate between two categorical variables. For means, the Student t-test was applied. We usually take baseline investigations before starting ATT (anti-TB treatment) with the blood sample we tested for vitamin D levels. Results With p-values of 0.767 and 0.866, the age and sex distributions in the cases and controls were comparable. Rural and urban area distribution and malnutrition distribution were not similar in both groups, with a p-value of 0.001. The mean vitamin D level in cases was 10.4, while controls it was 22.8, and this difference is statistically significant (p = 0.001). Conclusion Vitamin D deficiency is more common in children with TB than in normal children. In addition, a severe form of vitamin D deficiency (less than 10 ng/mL) was higher among children with TB. Clinicians should be aware of associated malnutrition and low socioeconomic status as risk factors for severe vitamin D deficiencies among them.
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spelling pubmed-103193572023-07-05 Serum Vitamin D Levels in Pediatric Tuberculosis Patients in a Tertiary Care Center in India: A Case-Control Study Ageeru, Karthik Mendu, Suresh Babu Avinash, Santhosh Kalyani, Srinivasa Kotha, Rakesh Cureus Pediatrics Background Mycobacterium is certainly one individual organism contributing to the most deaths of children among the world’s lower- and medium-income nations. According to earlier studies, vitamin D insufficiency is one of the risk factors. We undertook this study since very few case-control studies are present. This study aimed to evaluate the role of vitamin D in tuberculosis (TB). Methods This case-control study was carried out in a tertiary care center at Niloufer Hospital over a period of one year and five months. The sample size was 140. SPSS (Statistical Package for the Social Sciences) Version 19 (IBM Corp., Armonk, NY) was used for statistical analysis. Two-tailed p-values and odds ratios were obtained. The chi-square test was applied to differentiate between two categorical variables. For means, the Student t-test was applied. We usually take baseline investigations before starting ATT (anti-TB treatment) with the blood sample we tested for vitamin D levels. Results With p-values of 0.767 and 0.866, the age and sex distributions in the cases and controls were comparable. Rural and urban area distribution and malnutrition distribution were not similar in both groups, with a p-value of 0.001. The mean vitamin D level in cases was 10.4, while controls it was 22.8, and this difference is statistically significant (p = 0.001). Conclusion Vitamin D deficiency is more common in children with TB than in normal children. In addition, a severe form of vitamin D deficiency (less than 10 ng/mL) was higher among children with TB. Clinicians should be aware of associated malnutrition and low socioeconomic status as risk factors for severe vitamin D deficiencies among them. Cureus 2023-06-04 /pmc/articles/PMC10319357/ /pubmed/37409212 http://dx.doi.org/10.7759/cureus.39937 Text en Copyright © 2023, Ageeru et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pediatrics
Ageeru, Karthik
Mendu, Suresh Babu
Avinash, Santhosh
Kalyani, Srinivasa
Kotha, Rakesh
Serum Vitamin D Levels in Pediatric Tuberculosis Patients in a Tertiary Care Center in India: A Case-Control Study
title Serum Vitamin D Levels in Pediatric Tuberculosis Patients in a Tertiary Care Center in India: A Case-Control Study
title_full Serum Vitamin D Levels in Pediatric Tuberculosis Patients in a Tertiary Care Center in India: A Case-Control Study
title_fullStr Serum Vitamin D Levels in Pediatric Tuberculosis Patients in a Tertiary Care Center in India: A Case-Control Study
title_full_unstemmed Serum Vitamin D Levels in Pediatric Tuberculosis Patients in a Tertiary Care Center in India: A Case-Control Study
title_short Serum Vitamin D Levels in Pediatric Tuberculosis Patients in a Tertiary Care Center in India: A Case-Control Study
title_sort serum vitamin d levels in pediatric tuberculosis patients in a tertiary care center in india: a case-control study
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319357/
https://www.ncbi.nlm.nih.gov/pubmed/37409212
http://dx.doi.org/10.7759/cureus.39937
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