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The role of extravillous trophoblasts and uterine NK cells in vascular remodeling during pregnancy

Successful embryo implantation requires both a receptive endometrium and competent blastocysts. After implantation, the maternal decidua undergoes a series of changes, including uterine spiral artery (SA) remodeling to accommodate the fetus and provide nutrients and oxygen for the fetus to survive....

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Autores principales: Wei, Xiao-Wei, Zhang, Yu-Chen, Wu, Fan, Tian, Fu-Ju, Lin, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319396/
https://www.ncbi.nlm.nih.gov/pubmed/37408837
http://dx.doi.org/10.3389/fimmu.2022.951482
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author Wei, Xiao-Wei
Zhang, Yu-Chen
Wu, Fan
Tian, Fu-Ju
Lin, Yi
author_facet Wei, Xiao-Wei
Zhang, Yu-Chen
Wu, Fan
Tian, Fu-Ju
Lin, Yi
author_sort Wei, Xiao-Wei
collection PubMed
description Successful embryo implantation requires both a receptive endometrium and competent blastocysts. After implantation, the maternal decidua undergoes a series of changes, including uterine spiral artery (SA) remodeling to accommodate the fetus and provide nutrients and oxygen for the fetus to survive. Uterine spiral arteries transform from small-diameter, high-resistance arteries to large-diameter and low-resistance arteries during pregnancy. This transformation includes many changes, such as increased permeability and dilation of vessels, phenotypic switching and migration of vascular smooth muscle cells (VSMCs), transient loss of endothelial cells (ECs), endovascular invasion of extravillous trophoblasts (EVTs), and presence of intramural EVT, which are regulated by uterine NK (uNK) cells and EVTs. In this review, we mainly focus on the separate and combined roles of uNK cells and EVTs in uterine SA remodeling in establishing and maintaining pregnancy. New insight into related mechanisms will help us better understand the pathogenesis of pregnancy complications such as recurrent pregnancy loss (RPL) and preeclampsia (PE).
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spelling pubmed-103193962023-07-05 The role of extravillous trophoblasts and uterine NK cells in vascular remodeling during pregnancy Wei, Xiao-Wei Zhang, Yu-Chen Wu, Fan Tian, Fu-Ju Lin, Yi Front Immunol Immunology Successful embryo implantation requires both a receptive endometrium and competent blastocysts. After implantation, the maternal decidua undergoes a series of changes, including uterine spiral artery (SA) remodeling to accommodate the fetus and provide nutrients and oxygen for the fetus to survive. Uterine spiral arteries transform from small-diameter, high-resistance arteries to large-diameter and low-resistance arteries during pregnancy. This transformation includes many changes, such as increased permeability and dilation of vessels, phenotypic switching and migration of vascular smooth muscle cells (VSMCs), transient loss of endothelial cells (ECs), endovascular invasion of extravillous trophoblasts (EVTs), and presence of intramural EVT, which are regulated by uterine NK (uNK) cells and EVTs. In this review, we mainly focus on the separate and combined roles of uNK cells and EVTs in uterine SA remodeling in establishing and maintaining pregnancy. New insight into related mechanisms will help us better understand the pathogenesis of pregnancy complications such as recurrent pregnancy loss (RPL) and preeclampsia (PE). Frontiers Media S.A. 2022-07-22 /pmc/articles/PMC10319396/ /pubmed/37408837 http://dx.doi.org/10.3389/fimmu.2022.951482 Text en Copyright © 2022 Wei, Zhang, Wu, Tian and Lin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wei, Xiao-Wei
Zhang, Yu-Chen
Wu, Fan
Tian, Fu-Ju
Lin, Yi
The role of extravillous trophoblasts and uterine NK cells in vascular remodeling during pregnancy
title The role of extravillous trophoblasts and uterine NK cells in vascular remodeling during pregnancy
title_full The role of extravillous trophoblasts and uterine NK cells in vascular remodeling during pregnancy
title_fullStr The role of extravillous trophoblasts and uterine NK cells in vascular remodeling during pregnancy
title_full_unstemmed The role of extravillous trophoblasts and uterine NK cells in vascular remodeling during pregnancy
title_short The role of extravillous trophoblasts and uterine NK cells in vascular remodeling during pregnancy
title_sort role of extravillous trophoblasts and uterine nk cells in vascular remodeling during pregnancy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319396/
https://www.ncbi.nlm.nih.gov/pubmed/37408837
http://dx.doi.org/10.3389/fimmu.2022.951482
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