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Scaffold proteins of cancer signaling networks: The paradigm of FK506 binding protein 51 (FKBP51) supporting tumor intrinsic properties and immune escape

Scaffold proteins are crucial regulators of signaling networks, and their abnormal expression may favor the development of tumors. Among the scaffold proteins, immunophilin covers a unique role as ‘protein-philin’ (Greek ‘philin’ = friend) that interacts with proteins to guide their proper assembly....

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Autores principales: MARRONE, LAURA, D’AGOSTINO, MASSIMO, GIORDANO, CAROLINA, GIACOMO, VALERIA DI, URZINI, SIMONA, MALASOMMA, CHIARA, GAMMELLA, MARIA PAOLA, TUFANO, MARTINA, ROMANO, SIMONA, ROMANO, MARIA FIAMMETTA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tech Science Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319591/
https://www.ncbi.nlm.nih.gov/pubmed/37415743
http://dx.doi.org/10.32604/or.2023.028392
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author MARRONE, LAURA
D’AGOSTINO, MASSIMO
GIORDANO, CAROLINA
GIACOMO, VALERIA DI
URZINI, SIMONA
MALASOMMA, CHIARA
GAMMELLA, MARIA PAOLA
TUFANO, MARTINA
ROMANO, SIMONA
ROMANO, MARIA FIAMMETTA
author_facet MARRONE, LAURA
D’AGOSTINO, MASSIMO
GIORDANO, CAROLINA
GIACOMO, VALERIA DI
URZINI, SIMONA
MALASOMMA, CHIARA
GAMMELLA, MARIA PAOLA
TUFANO, MARTINA
ROMANO, SIMONA
ROMANO, MARIA FIAMMETTA
author_sort MARRONE, LAURA
collection PubMed
description Scaffold proteins are crucial regulators of signaling networks, and their abnormal expression may favor the development of tumors. Among the scaffold proteins, immunophilin covers a unique role as ‘protein-philin’ (Greek ‘philin’ = friend) that interacts with proteins to guide their proper assembly. The growing list of human syndromes associated with the immunophilin defect underscores the biological relevance of these proteins that are largely opportunistically exploited by cancer cells to support and enable the tumor’s intrinsic properties. Among the members of the immunophilin family, the FKBP5 gene was the only one identified to have a splicing variant. Cancer cells impose unique demands on the splicing machinery, thus acquiring a particular susceptibility to splicing inhibitors. This review article aims to overview the current knowledge of the FKBP5 gene functions in human cancer, illustrating how cancer cells exploit the scaffolding function of canonical FKBP51 to foster signaling networks that support their intrinsic tumor properties and the spliced FKBP51s to gain the capacity to evade the immune system.
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spelling pubmed-103195912023-07-06 Scaffold proteins of cancer signaling networks: The paradigm of FK506 binding protein 51 (FKBP51) supporting tumor intrinsic properties and immune escape MARRONE, LAURA D’AGOSTINO, MASSIMO GIORDANO, CAROLINA GIACOMO, VALERIA DI URZINI, SIMONA MALASOMMA, CHIARA GAMMELLA, MARIA PAOLA TUFANO, MARTINA ROMANO, SIMONA ROMANO, MARIA FIAMMETTA Oncol Res Review Scaffold proteins are crucial regulators of signaling networks, and their abnormal expression may favor the development of tumors. Among the scaffold proteins, immunophilin covers a unique role as ‘protein-philin’ (Greek ‘philin’ = friend) that interacts with proteins to guide their proper assembly. The growing list of human syndromes associated with the immunophilin defect underscores the biological relevance of these proteins that are largely opportunistically exploited by cancer cells to support and enable the tumor’s intrinsic properties. Among the members of the immunophilin family, the FKBP5 gene was the only one identified to have a splicing variant. Cancer cells impose unique demands on the splicing machinery, thus acquiring a particular susceptibility to splicing inhibitors. This review article aims to overview the current knowledge of the FKBP5 gene functions in human cancer, illustrating how cancer cells exploit the scaffolding function of canonical FKBP51 to foster signaling networks that support their intrinsic tumor properties and the spliced FKBP51s to gain the capacity to evade the immune system. Tech Science Press 2023-06-27 /pmc/articles/PMC10319591/ /pubmed/37415743 http://dx.doi.org/10.32604/or.2023.028392 Text en © 2023 Marrone et al. https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
MARRONE, LAURA
D’AGOSTINO, MASSIMO
GIORDANO, CAROLINA
GIACOMO, VALERIA DI
URZINI, SIMONA
MALASOMMA, CHIARA
GAMMELLA, MARIA PAOLA
TUFANO, MARTINA
ROMANO, SIMONA
ROMANO, MARIA FIAMMETTA
Scaffold proteins of cancer signaling networks: The paradigm of FK506 binding protein 51 (FKBP51) supporting tumor intrinsic properties and immune escape
title Scaffold proteins of cancer signaling networks: The paradigm of FK506 binding protein 51 (FKBP51) supporting tumor intrinsic properties and immune escape
title_full Scaffold proteins of cancer signaling networks: The paradigm of FK506 binding protein 51 (FKBP51) supporting tumor intrinsic properties and immune escape
title_fullStr Scaffold proteins of cancer signaling networks: The paradigm of FK506 binding protein 51 (FKBP51) supporting tumor intrinsic properties and immune escape
title_full_unstemmed Scaffold proteins of cancer signaling networks: The paradigm of FK506 binding protein 51 (FKBP51) supporting tumor intrinsic properties and immune escape
title_short Scaffold proteins of cancer signaling networks: The paradigm of FK506 binding protein 51 (FKBP51) supporting tumor intrinsic properties and immune escape
title_sort scaffold proteins of cancer signaling networks: the paradigm of fk506 binding protein 51 (fkbp51) supporting tumor intrinsic properties and immune escape
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319591/
https://www.ncbi.nlm.nih.gov/pubmed/37415743
http://dx.doi.org/10.32604/or.2023.028392
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