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Prognostic significance of osteosarcopenia in older adults with colorectal cancer

AIM: Osteopenia and sarcopenia, features of the aging process, are recognized as major health problems in an aging society. This study investigated the prognostic impact of osteosarcopenia, the coexistence of osteopenia and sarcopenia, in older adults undergoing curative resection for colorectal can...

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Autores principales: Takano, Yasuhiro, Kodera, Keita, Tsukihara, Shu, Takahashi, Sumika, Kobayashi, Yasunobu, Koyama, Muneyuki, Kanno, Hironori, Ishiyama, Satoshi, Hanyu, Nobuyoshi, Eto, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319614/
https://www.ncbi.nlm.nih.gov/pubmed/37416733
http://dx.doi.org/10.1002/ags3.12663
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author Takano, Yasuhiro
Kodera, Keita
Tsukihara, Shu
Takahashi, Sumika
Kobayashi, Yasunobu
Koyama, Muneyuki
Kanno, Hironori
Ishiyama, Satoshi
Hanyu, Nobuyoshi
Eto, Ken
author_facet Takano, Yasuhiro
Kodera, Keita
Tsukihara, Shu
Takahashi, Sumika
Kobayashi, Yasunobu
Koyama, Muneyuki
Kanno, Hironori
Ishiyama, Satoshi
Hanyu, Nobuyoshi
Eto, Ken
author_sort Takano, Yasuhiro
collection PubMed
description AIM: Osteopenia and sarcopenia, features of the aging process, are recognized as major health problems in an aging society. This study investigated the prognostic impact of osteosarcopenia, the coexistence of osteopenia and sarcopenia, in older adults undergoing curative resection for colorectal cancer. METHODS: We retrospectively reviewed data of older adults aged 65–98 y who had undergone curative resection for colorectal cancer. Osteopenia was evaluated by bone mineral density measurement in the midvertebral core of the 11th thoracic vertebra on preoperative computed tomography images. Sarcopenia was evaluated by measuring the skeletal muscle cross‐sectional area at the third lumbar vertebra level. Osteosarcopenia was defined as the coexistence of osteopenia and sarcopenia. We explored the relationship of preoperative osteosarcopenia with the disease‐free and overall survival after curative resection. RESULTS: Among the 325 patients included, those with osteosarcopenia had significantly lower overall survival rates than those with osteopenia or sarcopenia alone (P < 0.01). In the multivariate analysis, male sex (P = 0.045), C‐reactive protein‐to‐albumin ratio (P < 0.01), osteosarcopenia (P < 0.01), pathological T4 stage (P = 0.023), and pathological N1/N2 stage (P < 0.01) were independent predictors of disease‐free survival, while age (P < 0.01), male sex (P = 0.049), C‐reactive protein‐to‐albumin ratio (P < 0.01), osteosarcopenia (P < 0.01), pathological T4 stage (P = 0.036), pathological N1/N2 stage (P < 0.01), and carbohydrate antigen 19–9 (P = 0.041) were independent predictors of overall survival. CONCLUSION: Osteosarcopenia was a strong predictor of poor outcomes in older adults undergoing curative resection for colorectal cancer, suggesting an important role of osteosarcopenia in an aging society.
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spelling pubmed-103196142023-07-06 Prognostic significance of osteosarcopenia in older adults with colorectal cancer Takano, Yasuhiro Kodera, Keita Tsukihara, Shu Takahashi, Sumika Kobayashi, Yasunobu Koyama, Muneyuki Kanno, Hironori Ishiyama, Satoshi Hanyu, Nobuyoshi Eto, Ken Ann Gastroenterol Surg Original Articles AIM: Osteopenia and sarcopenia, features of the aging process, are recognized as major health problems in an aging society. This study investigated the prognostic impact of osteosarcopenia, the coexistence of osteopenia and sarcopenia, in older adults undergoing curative resection for colorectal cancer. METHODS: We retrospectively reviewed data of older adults aged 65–98 y who had undergone curative resection for colorectal cancer. Osteopenia was evaluated by bone mineral density measurement in the midvertebral core of the 11th thoracic vertebra on preoperative computed tomography images. Sarcopenia was evaluated by measuring the skeletal muscle cross‐sectional area at the third lumbar vertebra level. Osteosarcopenia was defined as the coexistence of osteopenia and sarcopenia. We explored the relationship of preoperative osteosarcopenia with the disease‐free and overall survival after curative resection. RESULTS: Among the 325 patients included, those with osteosarcopenia had significantly lower overall survival rates than those with osteopenia or sarcopenia alone (P < 0.01). In the multivariate analysis, male sex (P = 0.045), C‐reactive protein‐to‐albumin ratio (P < 0.01), osteosarcopenia (P < 0.01), pathological T4 stage (P = 0.023), and pathological N1/N2 stage (P < 0.01) were independent predictors of disease‐free survival, while age (P < 0.01), male sex (P = 0.049), C‐reactive protein‐to‐albumin ratio (P < 0.01), osteosarcopenia (P < 0.01), pathological T4 stage (P = 0.036), pathological N1/N2 stage (P < 0.01), and carbohydrate antigen 19–9 (P = 0.041) were independent predictors of overall survival. CONCLUSION: Osteosarcopenia was a strong predictor of poor outcomes in older adults undergoing curative resection for colorectal cancer, suggesting an important role of osteosarcopenia in an aging society. John Wiley and Sons Inc. 2023-02-20 /pmc/articles/PMC10319614/ /pubmed/37416733 http://dx.doi.org/10.1002/ags3.12663 Text en © 2023 The Authors. Annals of Gastroenterological Surgery published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Gastroenterological Surgery. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Takano, Yasuhiro
Kodera, Keita
Tsukihara, Shu
Takahashi, Sumika
Kobayashi, Yasunobu
Koyama, Muneyuki
Kanno, Hironori
Ishiyama, Satoshi
Hanyu, Nobuyoshi
Eto, Ken
Prognostic significance of osteosarcopenia in older adults with colorectal cancer
title Prognostic significance of osteosarcopenia in older adults with colorectal cancer
title_full Prognostic significance of osteosarcopenia in older adults with colorectal cancer
title_fullStr Prognostic significance of osteosarcopenia in older adults with colorectal cancer
title_full_unstemmed Prognostic significance of osteosarcopenia in older adults with colorectal cancer
title_short Prognostic significance of osteosarcopenia in older adults with colorectal cancer
title_sort prognostic significance of osteosarcopenia in older adults with colorectal cancer
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319614/
https://www.ncbi.nlm.nih.gov/pubmed/37416733
http://dx.doi.org/10.1002/ags3.12663
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