LGR4 and LGR5 form distinct homodimers that only LGR4 complexes with RNF43/ZNRF3 to provide high affinity binding of R-spondin ligands

LGR4 and LGR5 are two homologous receptors that potentiate Wnt/β-catenin signaling in response to R-spondin (RSPO) ligands. The RSPO and LGR4 complex binds to and inhibits activities of two related E3 ubiquitin ligases, RNF43 and ZNRF3, and thus protects Wnt receptors from the E3 ligase-mediated deg...

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Detalles Bibliográficos
Autores principales: Toh, Yukimatsu, Wu, Ling, Park, Soohyun, Wang, Allison, Tu, Jianghua, Yu, Wangsheng, Zuo, Mingxin, Carmon, Kendra S., Liu, Qingyun J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319729/
https://www.ncbi.nlm.nih.gov/pubmed/37402772
http://dx.doi.org/10.1038/s41598-023-37856-w

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