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Dynamic functional thalamocortical dysconnectivity in schizophrenia correlates to antipsychotics response
Although many studies have showed abnormal thalamocortical networks in patients with schizophrenia (SCZ), the dynamic functional thalamocortical connectivity of individuals with SCZ and the effect of antipsychotics on this connectivity have not been investigated. Drug-naïve first-episode individuals...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319786/ https://www.ncbi.nlm.nih.gov/pubmed/37402747 http://dx.doi.org/10.1038/s41537-023-00371-y |
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author | Yang, Mi Liu, Liju Cui, Hongmei Deng, Chijun Xiong, Weisen Zhao, Guocheng Du, Shulin Kosten, Thomas R. Chen, Huafu Li, Zezhi Zhang, Xiangyang |
author_facet | Yang, Mi Liu, Liju Cui, Hongmei Deng, Chijun Xiong, Weisen Zhao, Guocheng Du, Shulin Kosten, Thomas R. Chen, Huafu Li, Zezhi Zhang, Xiangyang |
author_sort | Yang, Mi |
collection | PubMed |
description | Although many studies have showed abnormal thalamocortical networks in patients with schizophrenia (SCZ), the dynamic functional thalamocortical connectivity of individuals with SCZ and the effect of antipsychotics on this connectivity have not been investigated. Drug-naïve first-episode individuals with SCZ and healthy controls were recruited. Patients were treated with risperidone for 12 weeks. Resting-state functional magnetic resonance imaging was acquired at baseline and week 12. We identified six functional thalamic subdivisions. The sliding window strategy was used to determine the dynamic functional connectivity (dFC) of each functional thalamic subdivision. Individuals with SCZ displayed decreased or increased dFC variance in different thalamic subdivisions. The baseline dFC between ventral posterior-lateral (VPL) portions and right dorsolateral superior frontal gyrus (rdSFG) correlated with psychotic symptoms. The dFC variance between VPL and right medial orbital superior frontal gyrus (rmoSFG) or rdSFG decreased after 12-week risperidone treatment. The decreased dFC variance between VPL and rmoSFG correlated with the reduction of PANSS scores. Interestingly, the dFC between VPL and rmoSFG or rdSFG decreased in responders. The dFC variance change of VPL and the averaged whole brain signal correlated with the risperidone efficacy. Our study demonstrates abnormal variability in thalamocortical dFC may be implicated in psychopathological symptoms and risperidone response in individuals with schizophrenia, suggesting that thalamocortical dFC variance may be correlated to the efficacy of antipsychotic treatment. Registration: ClinicalTrials.gov Identifier: NCT00435370. https://www.clinicaltrials.gov/ct2/show/NCT00435370?term=NCT00435370&draw=2&rank=1 |
format | Online Article Text |
id | pubmed-10319786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-103197862023-07-06 Dynamic functional thalamocortical dysconnectivity in schizophrenia correlates to antipsychotics response Yang, Mi Liu, Liju Cui, Hongmei Deng, Chijun Xiong, Weisen Zhao, Guocheng Du, Shulin Kosten, Thomas R. Chen, Huafu Li, Zezhi Zhang, Xiangyang Schizophrenia (Heidelb) Article Although many studies have showed abnormal thalamocortical networks in patients with schizophrenia (SCZ), the dynamic functional thalamocortical connectivity of individuals with SCZ and the effect of antipsychotics on this connectivity have not been investigated. Drug-naïve first-episode individuals with SCZ and healthy controls were recruited. Patients were treated with risperidone for 12 weeks. Resting-state functional magnetic resonance imaging was acquired at baseline and week 12. We identified six functional thalamic subdivisions. The sliding window strategy was used to determine the dynamic functional connectivity (dFC) of each functional thalamic subdivision. Individuals with SCZ displayed decreased or increased dFC variance in different thalamic subdivisions. The baseline dFC between ventral posterior-lateral (VPL) portions and right dorsolateral superior frontal gyrus (rdSFG) correlated with psychotic symptoms. The dFC variance between VPL and right medial orbital superior frontal gyrus (rmoSFG) or rdSFG decreased after 12-week risperidone treatment. The decreased dFC variance between VPL and rmoSFG correlated with the reduction of PANSS scores. Interestingly, the dFC between VPL and rmoSFG or rdSFG decreased in responders. The dFC variance change of VPL and the averaged whole brain signal correlated with the risperidone efficacy. Our study demonstrates abnormal variability in thalamocortical dFC may be implicated in psychopathological symptoms and risperidone response in individuals with schizophrenia, suggesting that thalamocortical dFC variance may be correlated to the efficacy of antipsychotic treatment. Registration: ClinicalTrials.gov Identifier: NCT00435370. https://www.clinicaltrials.gov/ct2/show/NCT00435370?term=NCT00435370&draw=2&rank=1 Nature Publishing Group UK 2023-07-04 /pmc/articles/PMC10319786/ /pubmed/37402747 http://dx.doi.org/10.1038/s41537-023-00371-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Yang, Mi Liu, Liju Cui, Hongmei Deng, Chijun Xiong, Weisen Zhao, Guocheng Du, Shulin Kosten, Thomas R. Chen, Huafu Li, Zezhi Zhang, Xiangyang Dynamic functional thalamocortical dysconnectivity in schizophrenia correlates to antipsychotics response |
title | Dynamic functional thalamocortical dysconnectivity in schizophrenia correlates to antipsychotics response |
title_full | Dynamic functional thalamocortical dysconnectivity in schizophrenia correlates to antipsychotics response |
title_fullStr | Dynamic functional thalamocortical dysconnectivity in schizophrenia correlates to antipsychotics response |
title_full_unstemmed | Dynamic functional thalamocortical dysconnectivity in schizophrenia correlates to antipsychotics response |
title_short | Dynamic functional thalamocortical dysconnectivity in schizophrenia correlates to antipsychotics response |
title_sort | dynamic functional thalamocortical dysconnectivity in schizophrenia correlates to antipsychotics response |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319786/ https://www.ncbi.nlm.nih.gov/pubmed/37402747 http://dx.doi.org/10.1038/s41537-023-00371-y |
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