Macrophage lineage cells-derived migrasomes activate complement-dependent blood-brain barrier damage in cerebral amyloid angiopathy mouse model

Accumulation of amyloid beta protein (Aβ) in brain vessels damages blood brain barrier (BBB) integrity in cerebral amyloid angiopathy (CAA). Macrophage lineage cells scavenge Aβ and produce disease-modifying mediators. Herein, we report that Aβ40-induced macrophage-derived migrasomes are sticky to b...

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Detalles Bibliográficos
Autores principales: Hu, Mengyan, Li, Tiemei, Ma, Xiaomeng, Liu, Sanxin, Li, Chunyi, Huang, Zhenchao, Lin, Yinyao, Wu, Ruizhen, Wang, Shisi, Lu, Danli, Lu, Tingting, Men, Xuejiao, Shen, Shishi, Huang, Huipeng, Liu, Yuxin, Song, Kangyu, Jian, Banghao, Jiang, Yuxuan, Qiu, Wei, Liu, Quentin, Lu, Zhengqi, Cai, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319857/
https://www.ncbi.nlm.nih.gov/pubmed/37402721
http://dx.doi.org/10.1038/s41467-023-39693-x

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