E3 ligase HECTD3 promotes RNA virus replication and virus-induced inflammation via K33-linked polyubiquitination of PKR

Uncontrolled viral replication and excessive inflammation are the main causes of death in the host infected with virus. Hence inhibition of intracellular viral replication and production of innate cytokines, which are the key strategies of hosts to fight virus infections, need to be finely tuned to...

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Detalles Bibliográficos
Autores principales: Huang, Jiaying, Yu, Zhou, Li, Xuelian, Yang, Mingjin, Fang, Qian, Li, Zheng, Wang, Chunmei, Chen, Taoyong, Cao, Xuetao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319860/
https://www.ncbi.nlm.nih.gov/pubmed/37402711
http://dx.doi.org/10.1038/s41419-023-05923-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319860/
https://www.ncbi.nlm.nih.gov/pubmed/37402711
http://dx.doi.org/10.1038/s41419-023-05923-9

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