Conservative surgical treatment with fertility preservation in a young adult with NTRK rearranged spindle cell neoplasm of the uterine cervix

In depth molecular studies are constantly expanding our understanding and refining the classification of gynecological neoplasms. NTRK rearranged spindle cell neoplasms of the lower genital tract are an emerging entity, of particular interest due to possible targeted treatment with selective kinase...

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Detalles Bibliográficos
Autores principales: Bühler, Marco M., Honcharova-Biletska, Hanna, Pauli, Chantal, Chronas, Dimitrios, Bolten, Kristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Survey Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319898/
https://www.ncbi.nlm.nih.gov/pubmed/37415959
http://dx.doi.org/10.1016/j.gore.2023.101233
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author Bühler, Marco M.
Honcharova-Biletska, Hanna
Pauli, Chantal
Chronas, Dimitrios
Bolten, Kristina
author_facet Bühler, Marco M.
Honcharova-Biletska, Hanna
Pauli, Chantal
Chronas, Dimitrios
Bolten, Kristina
author_sort Bühler, Marco M.
collection PubMed
description In depth molecular studies are constantly expanding our understanding and refining the classification of gynecological neoplasms. NTRK rearranged spindle cell neoplasms of the lower genital tract are an emerging entity, of particular interest due to possible targeted treatment with selective kinase inhibitors. Nonetheless, surgery remains the initial treatment of choice. We present the case of a 24-year-old patient suffering from a NTRK rearranged spindle cell neoplasm of the uterine cervix which was treated with a fertility preserving conservative surgical approach.
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spelling pubmed-103198982023-07-06 Conservative surgical treatment with fertility preservation in a young adult with NTRK rearranged spindle cell neoplasm of the uterine cervix Bühler, Marco M. Honcharova-Biletska, Hanna Pauli, Chantal Chronas, Dimitrios Bolten, Kristina Gynecol Oncol Rep Survey Article In depth molecular studies are constantly expanding our understanding and refining the classification of gynecological neoplasms. NTRK rearranged spindle cell neoplasms of the lower genital tract are an emerging entity, of particular interest due to possible targeted treatment with selective kinase inhibitors. Nonetheless, surgery remains the initial treatment of choice. We present the case of a 24-year-old patient suffering from a NTRK rearranged spindle cell neoplasm of the uterine cervix which was treated with a fertility preserving conservative surgical approach. Elsevier 2023-06-24 /pmc/articles/PMC10319898/ /pubmed/37415959 http://dx.doi.org/10.1016/j.gore.2023.101233 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Survey Article
Bühler, Marco M.
Honcharova-Biletska, Hanna
Pauli, Chantal
Chronas, Dimitrios
Bolten, Kristina
Conservative surgical treatment with fertility preservation in a young adult with NTRK rearranged spindle cell neoplasm of the uterine cervix
title Conservative surgical treatment with fertility preservation in a young adult with NTRK rearranged spindle cell neoplasm of the uterine cervix
title_full Conservative surgical treatment with fertility preservation in a young adult with NTRK rearranged spindle cell neoplasm of the uterine cervix
title_fullStr Conservative surgical treatment with fertility preservation in a young adult with NTRK rearranged spindle cell neoplasm of the uterine cervix
title_full_unstemmed Conservative surgical treatment with fertility preservation in a young adult with NTRK rearranged spindle cell neoplasm of the uterine cervix
title_short Conservative surgical treatment with fertility preservation in a young adult with NTRK rearranged spindle cell neoplasm of the uterine cervix
title_sort conservative surgical treatment with fertility preservation in a young adult with ntrk rearranged spindle cell neoplasm of the uterine cervix
topic Survey Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319898/
https://www.ncbi.nlm.nih.gov/pubmed/37415959
http://dx.doi.org/10.1016/j.gore.2023.101233
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