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Lane‐Hamilton syndrome

The co‐existence of idiopathic hemosiderosis and celiac disease is Lane‐Hamilton Syndrome. This is a rare condition with only a few dozen cases reported to date. Its clinical presentation typically involves hemoptysis that can be life‐threatening in the acute phase. We report the uncommon case of th...

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Detalles Bibliográficos
Autores principales: Grech, Audrey K., Yu, Christiaan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319957/
https://www.ncbi.nlm.nih.gov/pubmed/37416498
http://dx.doi.org/10.1002/rcr2.1188
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author Grech, Audrey K.
Yu, Christiaan
author_facet Grech, Audrey K.
Yu, Christiaan
author_sort Grech, Audrey K.
collection PubMed
description The co‐existence of idiopathic hemosiderosis and celiac disease is Lane‐Hamilton Syndrome. This is a rare condition with only a few dozen cases reported to date. Its clinical presentation typically involves hemoptysis that can be life‐threatening in the acute phase. We report the uncommon case of the development of idiopathic pulmonary hemosiderosis almost a decade after the diagnosis of celiac disease. Delayed diagnosis led to recurrent episodes of large volume hemoptysis despite immunosuppressive therapy due to ongoing ingestion of gluten. High doses of glucocorticoids accompanied by a cell cycle inhibitor mycophenolate mofetil were required for treatment. A strict gluten free diet is vital to control the disease. We highlight the importance of identifying this syndrome and definitive treatment, including avoidance of dietary triggers in addition to conventional immunosuppressive therapy.
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spelling pubmed-103199572023-07-06 Lane‐Hamilton syndrome Grech, Audrey K. Yu, Christiaan Respirol Case Rep Case Reports The co‐existence of idiopathic hemosiderosis and celiac disease is Lane‐Hamilton Syndrome. This is a rare condition with only a few dozen cases reported to date. Its clinical presentation typically involves hemoptysis that can be life‐threatening in the acute phase. We report the uncommon case of the development of idiopathic pulmonary hemosiderosis almost a decade after the diagnosis of celiac disease. Delayed diagnosis led to recurrent episodes of large volume hemoptysis despite immunosuppressive therapy due to ongoing ingestion of gluten. High doses of glucocorticoids accompanied by a cell cycle inhibitor mycophenolate mofetil were required for treatment. A strict gluten free diet is vital to control the disease. We highlight the importance of identifying this syndrome and definitive treatment, including avoidance of dietary triggers in addition to conventional immunosuppressive therapy. John Wiley & Sons, Ltd 2023-07-04 /pmc/articles/PMC10319957/ /pubmed/37416498 http://dx.doi.org/10.1002/rcr2.1188 Text en © 2023 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Grech, Audrey K.
Yu, Christiaan
Lane‐Hamilton syndrome
title Lane‐Hamilton syndrome
title_full Lane‐Hamilton syndrome
title_fullStr Lane‐Hamilton syndrome
title_full_unstemmed Lane‐Hamilton syndrome
title_short Lane‐Hamilton syndrome
title_sort lane‐hamilton syndrome
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319957/
https://www.ncbi.nlm.nih.gov/pubmed/37416498
http://dx.doi.org/10.1002/rcr2.1188
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