Docking and stability defects in mitofusin highlight the proteasome as a potential therapeutic target

Defects in mitochondrial fusion are at the base of many diseases. Mitofusins power membrane-remodeling events via self-interaction and GTP hydrolysis. However, how exactly mitofusins mediate fusion of the outer membrane is still unclear. Structural studies enable tailored design of mitofusin variant...

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Detalles Bibliográficos
Autores principales: Buntenbroich, Ira, Anton, Vincent, Perez-Hernandez, Daniel, Simões, Tânia, Gaedke, Felix, Schauss, Astrid, Dittmar, Gunnar, Riemer, Jan, Escobar-Henriques, Mafalda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320088/
https://www.ncbi.nlm.nih.gov/pubmed/37416455
http://dx.doi.org/10.1016/j.isci.2023.107014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320088/
https://www.ncbi.nlm.nih.gov/pubmed/37416455
http://dx.doi.org/10.1016/j.isci.2023.107014

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