The RSV F p27 peptide: current knowledge, important questions

Respiratory syncytial virus (RSV) remains a leading cause of hospitalizations and death for young children and adults over 65. The worldwide impact of RSV has prioritized the search for an RSV vaccine, with most targeting the critical fusion (F) protein. However, questions remain about the mechanism...

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Detalles Bibliográficos
Autores principales: Rezende, Wanderson, Neal, Hadley E., Dutch, Rebecca E., Piedra, Pedro A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320223/
https://www.ncbi.nlm.nih.gov/pubmed/37415824
http://dx.doi.org/10.3389/fmicb.2023.1219846
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author Rezende, Wanderson
Neal, Hadley E.
Dutch, Rebecca E.
Piedra, Pedro A.
author_facet Rezende, Wanderson
Neal, Hadley E.
Dutch, Rebecca E.
Piedra, Pedro A.
author_sort Rezende, Wanderson
collection PubMed
description Respiratory syncytial virus (RSV) remains a leading cause of hospitalizations and death for young children and adults over 65. The worldwide impact of RSV has prioritized the search for an RSV vaccine, with most targeting the critical fusion (F) protein. However, questions remain about the mechanism of RSV entry and RSV F triggering and fusion promotion. This review highlights these questions, specifically those surrounding a cleaved 27 amino acids long peptide within F, p27.
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spelling pubmed-103202232023-07-06 The RSV F p27 peptide: current knowledge, important questions Rezende, Wanderson Neal, Hadley E. Dutch, Rebecca E. Piedra, Pedro A. Front Microbiol Microbiology Respiratory syncytial virus (RSV) remains a leading cause of hospitalizations and death for young children and adults over 65. The worldwide impact of RSV has prioritized the search for an RSV vaccine, with most targeting the critical fusion (F) protein. However, questions remain about the mechanism of RSV entry and RSV F triggering and fusion promotion. This review highlights these questions, specifically those surrounding a cleaved 27 amino acids long peptide within F, p27. Frontiers Media S.A. 2023-06-21 /pmc/articles/PMC10320223/ /pubmed/37415824 http://dx.doi.org/10.3389/fmicb.2023.1219846 Text en Copyright © 2023 Rezende, Neal, Dutch and Piedra. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Rezende, Wanderson
Neal, Hadley E.
Dutch, Rebecca E.
Piedra, Pedro A.
The RSV F p27 peptide: current knowledge, important questions
title The RSV F p27 peptide: current knowledge, important questions
title_full The RSV F p27 peptide: current knowledge, important questions
title_fullStr The RSV F p27 peptide: current knowledge, important questions
title_full_unstemmed The RSV F p27 peptide: current knowledge, important questions
title_short The RSV F p27 peptide: current knowledge, important questions
title_sort rsv f p27 peptide: current knowledge, important questions
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320223/
https://www.ncbi.nlm.nih.gov/pubmed/37415824
http://dx.doi.org/10.3389/fmicb.2023.1219846
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