Exosomes derived from odontogenic stem cells: Its role in the dentin-pulp complex

Odontogenic stem cells originate from cranial neural crest cells and offer unique advantages in the regeneration of dentin-pulp complex. There is increasing evidence that stem cells exert their biological functions mainly through exosome-based paracrine effects. Exosomes contain DNA, RNA, proteins,...

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Autores principales: Zou, Jiyuan, Xia, Han, Jiang, Qianzhou, Su, Zhikang, Wen, Siyi, Liang, Zitian, Ouyang, Yuanting, Liu, Jiaohong, Zhang, Zhiyi, Chen, Ding, Yang, Li, Guo, Lvhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society for Regenerative Medicine 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320411/
https://www.ncbi.nlm.nih.gov/pubmed/37415682
http://dx.doi.org/10.1016/j.reth.2023.05.008
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author Zou, Jiyuan
Xia, Han
Jiang, Qianzhou
Su, Zhikang
Wen, Siyi
Liang, Zitian
Ouyang, Yuanting
Liu, Jiaohong
Zhang, Zhiyi
Chen, Ding
Yang, Li
Guo, Lvhua
author_facet Zou, Jiyuan
Xia, Han
Jiang, Qianzhou
Su, Zhikang
Wen, Siyi
Liang, Zitian
Ouyang, Yuanting
Liu, Jiaohong
Zhang, Zhiyi
Chen, Ding
Yang, Li
Guo, Lvhua
author_sort Zou, Jiyuan
collection PubMed
description Odontogenic stem cells originate from cranial neural crest cells and offer unique advantages in the regeneration of dentin-pulp complex. There is increasing evidence that stem cells exert their biological functions mainly through exosome-based paracrine effects. Exosomes contain DNA, RNA, proteins, metabolites, etc., which can play a role in intercellular communication and have similar therapeutic potential to stem cells. In addition, compared with stem cells, exosomes also have the advantages of good biocompatibility, high drug carrying capacity, easy to obtain, and few side effects. Odontogenic stem cell-derived exosomes mainly affect the regeneration of the dentin-pulp complex by regulating processes such as dentintogenesis, angiogenesis, neuroprotection and immunomodulation. This review aimed to describe “cell-free therapies” based on odontogenic stem cell-derived exosomes, which aim to regenerate the dentin-pulp complex.
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spelling pubmed-103204112023-07-06 Exosomes derived from odontogenic stem cells: Its role in the dentin-pulp complex Zou, Jiyuan Xia, Han Jiang, Qianzhou Su, Zhikang Wen, Siyi Liang, Zitian Ouyang, Yuanting Liu, Jiaohong Zhang, Zhiyi Chen, Ding Yang, Li Guo, Lvhua Regen Ther Review Odontogenic stem cells originate from cranial neural crest cells and offer unique advantages in the regeneration of dentin-pulp complex. There is increasing evidence that stem cells exert their biological functions mainly through exosome-based paracrine effects. Exosomes contain DNA, RNA, proteins, metabolites, etc., which can play a role in intercellular communication and have similar therapeutic potential to stem cells. In addition, compared with stem cells, exosomes also have the advantages of good biocompatibility, high drug carrying capacity, easy to obtain, and few side effects. Odontogenic stem cell-derived exosomes mainly affect the regeneration of the dentin-pulp complex by regulating processes such as dentintogenesis, angiogenesis, neuroprotection and immunomodulation. This review aimed to describe “cell-free therapies” based on odontogenic stem cell-derived exosomes, which aim to regenerate the dentin-pulp complex. Japanese Society for Regenerative Medicine 2023-06-22 /pmc/articles/PMC10320411/ /pubmed/37415682 http://dx.doi.org/10.1016/j.reth.2023.05.008 Text en © 2023 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Zou, Jiyuan
Xia, Han
Jiang, Qianzhou
Su, Zhikang
Wen, Siyi
Liang, Zitian
Ouyang, Yuanting
Liu, Jiaohong
Zhang, Zhiyi
Chen, Ding
Yang, Li
Guo, Lvhua
Exosomes derived from odontogenic stem cells: Its role in the dentin-pulp complex
title Exosomes derived from odontogenic stem cells: Its role in the dentin-pulp complex
title_full Exosomes derived from odontogenic stem cells: Its role in the dentin-pulp complex
title_fullStr Exosomes derived from odontogenic stem cells: Its role in the dentin-pulp complex
title_full_unstemmed Exosomes derived from odontogenic stem cells: Its role in the dentin-pulp complex
title_short Exosomes derived from odontogenic stem cells: Its role in the dentin-pulp complex
title_sort exosomes derived from odontogenic stem cells: its role in the dentin-pulp complex
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320411/
https://www.ncbi.nlm.nih.gov/pubmed/37415682
http://dx.doi.org/10.1016/j.reth.2023.05.008
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