mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8(+) T and NK Cells to Generate Antitumor Immunity

IL-12 is a pleotropic inflammatory cytokine, which has broad stimulatory effects on various immune cell populations, making it an attractive target for cancer immunotherapy. However, despite generating robust antitumor activity in syngeneic murine tumor models, clinical administration of IL-12 has b...

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Detalles Bibliográficos
Autores principales: Nirschl, Christopher J., Brodkin, Heather R., Domonkos, Celesztina, Dwyer, Connor J., Hicklin, Daniel J., Ismail, Nesreen, Seidel-Dugan, Cynthia, Steiner, Philipp, Steuert, Zoe, Sullivan, Jenna M., Winston, William M., Salmeron, Andres
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320472/
https://www.ncbi.nlm.nih.gov/pubmed/37074216
http://dx.doi.org/10.1158/2326-6066.CIR-22-0705

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