Truncation of GalNAc-type O-glycans Suppresses CD44-mediated Osteoclastogenesis and Bone Metastasis in Breast Cancer

The glycoprotein CD44 is a key regulator of malignant behaviors in breast cancer cells. To date, hyaluronic acid (HA)-CD44 signaling pathway has been widely documented in the context of metastatic bone diseases. Core 1 β1,3-galactosyltransferase (C1GALT1) is a critical enzyme responsible for the elo...

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Detalles Bibliográficos
Autores principales: Lin, Neng-Yu, Lee, Jian-Jr, Chen, Syue-Ting, Lin, Jung-An, Lin, Chia-Hsuan, Lin, Hsuan-Yu, Su, Yong-Han, Chen, Cheng-Chang, Lin, Mei-Chun, Kuo, Ching-Ying, Huang, Min-Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Cancer Genes and Networks
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320474/
https://www.ncbi.nlm.nih.gov/pubmed/37040171
http://dx.doi.org/10.1158/1541-7786.MCR-22-0907

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