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The Preclinical Pharmacology of Tepotinib—A Highly Selective MET Inhibitor with Activity in Tumors Harboring MET Alterations

The mesenchymal–epithelial transition factor (MET) proto-oncogene encodes the MET receptor tyrosine kinase. MET aberrations drive tumorigenesis in several cancer types through a variety of molecular mechanisms, including MET mutations, gene amplification, rearrangement, and overexpression. Therefore...

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Detalles Bibliográficos
Autores principales:	Albers, Joachim, Friese-Hamim, Manja, Clark, Anderson, Schadt, Oliver, Walter-Bausch, Gina, Stroh, Christopher, Johne, Andreas, Karachaliou, Niki, Blaukat, Andree
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320478/ https://www.ncbi.nlm.nih.gov/pubmed/36999986 http://dx.doi.org/10.1158/1535-7163.MCT-22-0537

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