Selective Inhibition of ATM-dependent Double-strand Break Repair and Checkpoint Control Synergistically Enhances the Efficacy of ATR Inhibitors

Ataxia telangiectasia and Rad3-related protein (ATR) kinase regulate a key cell regulatory node for maintaining genomic integrity by preventing replication fork collapse. ATR inhibition has been shown to increase replication stress resulting in DNA double-strand breaks (DSBs) and cancer cell death,...

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Detalles Bibliográficos
Autores principales: Turchick, Audrey, Zimmermann, Astrid, Chiu, Li-Ya, Dahmen, Heike, Elenbaas, Brian, Zenke, Frank T., Blaukat, Andree, Vassilev, Lyubomir T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Small Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320480/
https://www.ncbi.nlm.nih.gov/pubmed/37079339
http://dx.doi.org/10.1158/1535-7163.MCT-22-0685

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