Tyrosine Kinase Inhibitors Diminish Renal Neoplasms in a Tuberous Sclerosis Model Via Induction of Apoptosis

Tuberous sclerosis complex (TSC) tumors are presently incurable despite a cytostatic response to mTOR pathway inhibition because recurrence of disease occurs after treatment is discontinued. Here, we explored the hypothesis that inhibiting tyrosine kinase activity in mesenchymal lineage-specific pla...

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Detalles Bibliográficos
Autores principales: Unachukwu, Uchenna, Sonett, Jarrod, Woode, Denzel, Shiomi, Takayuki, Chada, Kiran, D'Armiento, Jeanine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Small Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320481/
https://www.ncbi.nlm.nih.gov/pubmed/37127876
http://dx.doi.org/10.1158/1535-7163.MCT-22-0224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320481/
https://www.ncbi.nlm.nih.gov/pubmed/37127876
http://dx.doi.org/10.1158/1535-7163.MCT-22-0224

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