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Mu-opioid receptor selective superagonists produce prolonged respiratory depression

Synthetic opioids are increasingly challenging to combat the opioid epidemic and act primarily at opioid receptors, chiefly the G protein-coupled receptor (GPCR) μ-opioid receptor (MOR), which signals through G protein-dependent and β-arrestin pathways. Using a bioluminescence resonance energy trans...

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Detalles Bibliográficos
Autores principales:	Malcolm, Nicholas J., Palkovic, Barbara, Sprague, Daniel J., Calkins, Maggie M., Lanham, Janelle K., Halberstadt, Adam L., Stucke, Astrid G., McCorvy, John D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320493/ https://www.ncbi.nlm.nih.gov/pubmed/37416459 http://dx.doi.org/10.1016/j.isci.2023.107121

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