Differential pairing of transmembrane domain GxxxG dimerization motifs defines two HLA-DR MHC class II conformers

MHC class II molecules function to present exogenous antigen-derived peptides to CD4 T cells to both drive T cell activation and to provide signals back into the class II antigen-presenting cell. Previous work established the presence of multiple GxxxG dimerization motifs within the transmembrane do...

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Detalles Bibliográficos
Autores principales: Drake, Lisa A., Hahn, Amy B., Dixon, Ann M., Drake, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320510/
https://www.ncbi.nlm.nih.gov/pubmed/37247758
http://dx.doi.org/10.1016/j.jbc.2023.104869

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