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Phosphorylation of spleen tyrosine kinase at Y346 negatively regulates ITAM-mediated signaling and function in platelets

Spleen tyrosine kinase (Syk) is expressed in a variety of hemopoietic cells. Upon phosphorylation of the platelet immunoreceptor–based activation motif of the glycoprotein VI (GPVI)/Fc receptor gamma chain collagen receptor, both the tyrosine phosphorylation and activity of Syk are increased leading...

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Detalles Bibliográficos
Autores principales:	Dangelmaier, Carol A., Patchin, Margaret, Vajipayajula, Dhruv N., Vari, Hymavathi Reddy, Singh, Pankaj K., Wright, Monica N., Kostyak, John C., Tsygankov, Alexander Y., Kunapuli, Satya P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article Collection: Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320515/ https://www.ncbi.nlm.nih.gov/pubmed/37268160 http://dx.doi.org/10.1016/j.jbc.2023.104865

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