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Enhancing the anticancer immune response with the assistance of drug repurposing and delivery systems
BACKGROUND: The immune system plays a pivotal role in the initiation, evolution, invasion and metastasis of cancer. Therapeutics aiming at modulating or boosting anticancer immune responses have experienced immense advances during the past decades, for example, anti‐PD‐1/PD‐L1 monoclonal antibodies....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320767/ https://www.ncbi.nlm.nih.gov/pubmed/37403792 http://dx.doi.org/10.1002/ctm2.1320 |
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author | Fu, Zile Zhang, Xiaoming Gao, Yanfeng Fan, Jia Gao, Qiang |
author_facet | Fu, Zile Zhang, Xiaoming Gao, Yanfeng Fan, Jia Gao, Qiang |
author_sort | Fu, Zile |
collection | PubMed |
description | BACKGROUND: The immune system plays a pivotal role in the initiation, evolution, invasion and metastasis of cancer. Therapeutics aiming at modulating or boosting anticancer immune responses have experienced immense advances during the past decades, for example, anti‐PD‐1/PD‐L1 monoclonal antibodies. MAIN BODY: Concomitant with advancements in the understanding of novel mechanisms of action, conventional or emerging drugs bearing the potential to be repurposed for enhancing anticancer immunity have been identified. Meanwhile, ongoing advances in drug delivery systems enable us to utilise novel therapeutic strategies and impart drugs with fresh modes of action in tumour immunology. CONCLUSION: Herein, we systemically review these kinds of drugs and delivery systems that can unleash the anticancer response through various aspects, including immune recognition, activation, infiltration and tumour killing. We also discuss the current caveats and future directions of these emerging strategies. |
format | Online Article Text |
id | pubmed-10320767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103207672023-07-06 Enhancing the anticancer immune response with the assistance of drug repurposing and delivery systems Fu, Zile Zhang, Xiaoming Gao, Yanfeng Fan, Jia Gao, Qiang Clin Transl Med Reviews BACKGROUND: The immune system plays a pivotal role in the initiation, evolution, invasion and metastasis of cancer. Therapeutics aiming at modulating or boosting anticancer immune responses have experienced immense advances during the past decades, for example, anti‐PD‐1/PD‐L1 monoclonal antibodies. MAIN BODY: Concomitant with advancements in the understanding of novel mechanisms of action, conventional or emerging drugs bearing the potential to be repurposed for enhancing anticancer immunity have been identified. Meanwhile, ongoing advances in drug delivery systems enable us to utilise novel therapeutic strategies and impart drugs with fresh modes of action in tumour immunology. CONCLUSION: Herein, we systemically review these kinds of drugs and delivery systems that can unleash the anticancer response through various aspects, including immune recognition, activation, infiltration and tumour killing. We also discuss the current caveats and future directions of these emerging strategies. John Wiley and Sons Inc. 2023-07-05 /pmc/articles/PMC10320767/ /pubmed/37403792 http://dx.doi.org/10.1002/ctm2.1320 Text en © 2023 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Fu, Zile Zhang, Xiaoming Gao, Yanfeng Fan, Jia Gao, Qiang Enhancing the anticancer immune response with the assistance of drug repurposing and delivery systems |
title | Enhancing the anticancer immune response with the assistance of drug repurposing and delivery systems |
title_full | Enhancing the anticancer immune response with the assistance of drug repurposing and delivery systems |
title_fullStr | Enhancing the anticancer immune response with the assistance of drug repurposing and delivery systems |
title_full_unstemmed | Enhancing the anticancer immune response with the assistance of drug repurposing and delivery systems |
title_short | Enhancing the anticancer immune response with the assistance of drug repurposing and delivery systems |
title_sort | enhancing the anticancer immune response with the assistance of drug repurposing and delivery systems |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320767/ https://www.ncbi.nlm.nih.gov/pubmed/37403792 http://dx.doi.org/10.1002/ctm2.1320 |
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