Cargando…
Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease
Systemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells in early disease stages remain ill defined. Chronic obstructive pulmonary disease (COPD) is a major respiratory disease characterized by small-...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320832/ https://www.ncbi.nlm.nih.gov/pubmed/37243592 http://dx.doi.org/10.1016/j.celrep.2023.112525 |
_version_ | 1785068510635884544 |
---|---|
author | Kapellos, Theodore S. Baßler, Kevin Fujii, Wataru Nalkurthi, Christina Schaar, Anna C. Bonaguro, Lorenzo Pecht, Tal Galvao, Izabela Agrawal, Shobhit Saglam, Adem Dudkin, Erica Frishberg, Amit de Domenico, Elena Horne, Arik Donovan, Chantal Kim, Richard Y. Gallego-Ortega, David Gillett, Tessa E. Ansari, Meshal Schulte-Schrepping, Jonas Offermann, Nina Antignano, Ignazio Sivri, Burcu Lu, Wenying Eapen, Mathew S. van Uelft, Martina Osei-Sarpong, Collins van den Berge, Maarten Donker, Hylke C. Groen, Harry J.M. Sohal, Sukhwinder S. Klein, Johanna Schreiber, Tina Feißt, Andreas Yildirim, Ali Önder Schiller, Herbert B. Nawijn, Martijn C. Becker, Matthias Händler, Kristian Beyer, Marc Capasso, Melania Ulas, Thomas Hasenauer, Jan Pizarro, Carmen Theis, Fabian J. Hansbro, Philip M. Skowasch, Dirk Schultze, Joachim L. |
author_facet | Kapellos, Theodore S. Baßler, Kevin Fujii, Wataru Nalkurthi, Christina Schaar, Anna C. Bonaguro, Lorenzo Pecht, Tal Galvao, Izabela Agrawal, Shobhit Saglam, Adem Dudkin, Erica Frishberg, Amit de Domenico, Elena Horne, Arik Donovan, Chantal Kim, Richard Y. Gallego-Ortega, David Gillett, Tessa E. Ansari, Meshal Schulte-Schrepping, Jonas Offermann, Nina Antignano, Ignazio Sivri, Burcu Lu, Wenying Eapen, Mathew S. van Uelft, Martina Osei-Sarpong, Collins van den Berge, Maarten Donker, Hylke C. Groen, Harry J.M. Sohal, Sukhwinder S. Klein, Johanna Schreiber, Tina Feißt, Andreas Yildirim, Ali Önder Schiller, Herbert B. Nawijn, Martijn C. Becker, Matthias Händler, Kristian Beyer, Marc Capasso, Melania Ulas, Thomas Hasenauer, Jan Pizarro, Carmen Theis, Fabian J. Hansbro, Philip M. Skowasch, Dirk Schultze, Joachim L. |
author_sort | Kapellos, Theodore S. |
collection | PubMed |
description | Systemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells in early disease stages remain ill defined. Chronic obstructive pulmonary disease (COPD) is a major respiratory disease characterized by small-airway inflammation, emphysema, and severe breathing difficulties. Using single-cell analyses we demonstrate that blood neutrophils are already increased in early-stage COPD, and changes in molecular and functional neutrophil states correlate with lung function decline. Assessing neutrophils and their bone marrow precursors in a murine cigarette smoke exposure model identified similar molecular changes in blood neutrophils and precursor populations that also occur in the blood and lung. Our study shows that systemic molecular alterations in neutrophils and their precursors are part of early-stage COPD, a finding to be further explored for potential therapeutic targets and biomarkers for early diagnosis and patient stratification. |
format | Online Article Text |
id | pubmed-10320832 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cell Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-103208322023-07-06 Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease Kapellos, Theodore S. Baßler, Kevin Fujii, Wataru Nalkurthi, Christina Schaar, Anna C. Bonaguro, Lorenzo Pecht, Tal Galvao, Izabela Agrawal, Shobhit Saglam, Adem Dudkin, Erica Frishberg, Amit de Domenico, Elena Horne, Arik Donovan, Chantal Kim, Richard Y. Gallego-Ortega, David Gillett, Tessa E. Ansari, Meshal Schulte-Schrepping, Jonas Offermann, Nina Antignano, Ignazio Sivri, Burcu Lu, Wenying Eapen, Mathew S. van Uelft, Martina Osei-Sarpong, Collins van den Berge, Maarten Donker, Hylke C. Groen, Harry J.M. Sohal, Sukhwinder S. Klein, Johanna Schreiber, Tina Feißt, Andreas Yildirim, Ali Önder Schiller, Herbert B. Nawijn, Martijn C. Becker, Matthias Händler, Kristian Beyer, Marc Capasso, Melania Ulas, Thomas Hasenauer, Jan Pizarro, Carmen Theis, Fabian J. Hansbro, Philip M. Skowasch, Dirk Schultze, Joachim L. Cell Rep Article Systemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells in early disease stages remain ill defined. Chronic obstructive pulmonary disease (COPD) is a major respiratory disease characterized by small-airway inflammation, emphysema, and severe breathing difficulties. Using single-cell analyses we demonstrate that blood neutrophils are already increased in early-stage COPD, and changes in molecular and functional neutrophil states correlate with lung function decline. Assessing neutrophils and their bone marrow precursors in a murine cigarette smoke exposure model identified similar molecular changes in blood neutrophils and precursor populations that also occur in the blood and lung. Our study shows that systemic molecular alterations in neutrophils and their precursors are part of early-stage COPD, a finding to be further explored for potential therapeutic targets and biomarkers for early diagnosis and patient stratification. Cell Press 2023-05-26 /pmc/articles/PMC10320832/ /pubmed/37243592 http://dx.doi.org/10.1016/j.celrep.2023.112525 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Kapellos, Theodore S. Baßler, Kevin Fujii, Wataru Nalkurthi, Christina Schaar, Anna C. Bonaguro, Lorenzo Pecht, Tal Galvao, Izabela Agrawal, Shobhit Saglam, Adem Dudkin, Erica Frishberg, Amit de Domenico, Elena Horne, Arik Donovan, Chantal Kim, Richard Y. Gallego-Ortega, David Gillett, Tessa E. Ansari, Meshal Schulte-Schrepping, Jonas Offermann, Nina Antignano, Ignazio Sivri, Burcu Lu, Wenying Eapen, Mathew S. van Uelft, Martina Osei-Sarpong, Collins van den Berge, Maarten Donker, Hylke C. Groen, Harry J.M. Sohal, Sukhwinder S. Klein, Johanna Schreiber, Tina Feißt, Andreas Yildirim, Ali Önder Schiller, Herbert B. Nawijn, Martijn C. Becker, Matthias Händler, Kristian Beyer, Marc Capasso, Melania Ulas, Thomas Hasenauer, Jan Pizarro, Carmen Theis, Fabian J. Hansbro, Philip M. Skowasch, Dirk Schultze, Joachim L. Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease |
title | Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease |
title_full | Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease |
title_fullStr | Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease |
title_full_unstemmed | Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease |
title_short | Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease |
title_sort | systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320832/ https://www.ncbi.nlm.nih.gov/pubmed/37243592 http://dx.doi.org/10.1016/j.celrep.2023.112525 |
work_keys_str_mv | AT kapellostheodores systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT baßlerkevin systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT fujiiwataru systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT nalkurthichristina systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT schaarannac systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT bonagurolorenzo systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT pechttal systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT galvaoizabela systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT agrawalshobhit systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT saglamadem systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT dudkinerica systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT frishbergamit systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT dedomenicoelena systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT hornearik systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT donovanchantal systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT kimrichardy systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT gallegoortegadavid systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT gilletttessae systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT ansarimeshal systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT schulteschreppingjonas systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT offermannnina systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT antignanoignazio systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT sivriburcu systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT luwenying systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT eapenmathews systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT vanuelftmartina systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT oseisarpongcollins systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT vandenbergemaarten systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT donkerhylkec systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT groenharryjm systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT sohalsukhwinders systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT kleinjohanna systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT schreibertina systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT feißtandreas systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT yildirimalionder systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT schillerherbertb systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT nawijnmartijnc systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT beckermatthias systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT handlerkristian systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT beyermarc systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT capassomelania systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT ulasthomas systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT hasenauerjan systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT pizarrocarmen systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT theisfabianj systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT hansbrophilipm systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT skowaschdirk systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease AT schultzejoachiml systemicalterationsinneutrophilsandtheirprecursorsinearlystagechronicobstructivepulmonarydisease |