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Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease

Systemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells in early disease stages remain ill defined. Chronic obstructive pulmonary disease (COPD) is a major respiratory disease characterized by small-...

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Autores principales: Kapellos, Theodore S., Baßler, Kevin, Fujii, Wataru, Nalkurthi, Christina, Schaar, Anna C., Bonaguro, Lorenzo, Pecht, Tal, Galvao, Izabela, Agrawal, Shobhit, Saglam, Adem, Dudkin, Erica, Frishberg, Amit, de Domenico, Elena, Horne, Arik, Donovan, Chantal, Kim, Richard Y., Gallego-Ortega, David, Gillett, Tessa E., Ansari, Meshal, Schulte-Schrepping, Jonas, Offermann, Nina, Antignano, Ignazio, Sivri, Burcu, Lu, Wenying, Eapen, Mathew S., van Uelft, Martina, Osei-Sarpong, Collins, van den Berge, Maarten, Donker, Hylke C., Groen, Harry J.M., Sohal, Sukhwinder S., Klein, Johanna, Schreiber, Tina, Feißt, Andreas, Yildirim, Ali Önder, Schiller, Herbert B., Nawijn, Martijn C., Becker, Matthias, Händler, Kristian, Beyer, Marc, Capasso, Melania, Ulas, Thomas, Hasenauer, Jan, Pizarro, Carmen, Theis, Fabian J., Hansbro, Philip M., Skowasch, Dirk, Schultze, Joachim L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320832/
https://www.ncbi.nlm.nih.gov/pubmed/37243592
http://dx.doi.org/10.1016/j.celrep.2023.112525
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author Kapellos, Theodore S.
Baßler, Kevin
Fujii, Wataru
Nalkurthi, Christina
Schaar, Anna C.
Bonaguro, Lorenzo
Pecht, Tal
Galvao, Izabela
Agrawal, Shobhit
Saglam, Adem
Dudkin, Erica
Frishberg, Amit
de Domenico, Elena
Horne, Arik
Donovan, Chantal
Kim, Richard Y.
Gallego-Ortega, David
Gillett, Tessa E.
Ansari, Meshal
Schulte-Schrepping, Jonas
Offermann, Nina
Antignano, Ignazio
Sivri, Burcu
Lu, Wenying
Eapen, Mathew S.
van Uelft, Martina
Osei-Sarpong, Collins
van den Berge, Maarten
Donker, Hylke C.
Groen, Harry J.M.
Sohal, Sukhwinder S.
Klein, Johanna
Schreiber, Tina
Feißt, Andreas
Yildirim, Ali Önder
Schiller, Herbert B.
Nawijn, Martijn C.
Becker, Matthias
Händler, Kristian
Beyer, Marc
Capasso, Melania
Ulas, Thomas
Hasenauer, Jan
Pizarro, Carmen
Theis, Fabian J.
Hansbro, Philip M.
Skowasch, Dirk
Schultze, Joachim L.
author_facet Kapellos, Theodore S.
Baßler, Kevin
Fujii, Wataru
Nalkurthi, Christina
Schaar, Anna C.
Bonaguro, Lorenzo
Pecht, Tal
Galvao, Izabela
Agrawal, Shobhit
Saglam, Adem
Dudkin, Erica
Frishberg, Amit
de Domenico, Elena
Horne, Arik
Donovan, Chantal
Kim, Richard Y.
Gallego-Ortega, David
Gillett, Tessa E.
Ansari, Meshal
Schulte-Schrepping, Jonas
Offermann, Nina
Antignano, Ignazio
Sivri, Burcu
Lu, Wenying
Eapen, Mathew S.
van Uelft, Martina
Osei-Sarpong, Collins
van den Berge, Maarten
Donker, Hylke C.
Groen, Harry J.M.
Sohal, Sukhwinder S.
Klein, Johanna
Schreiber, Tina
Feißt, Andreas
Yildirim, Ali Önder
Schiller, Herbert B.
Nawijn, Martijn C.
Becker, Matthias
Händler, Kristian
Beyer, Marc
Capasso, Melania
Ulas, Thomas
Hasenauer, Jan
Pizarro, Carmen
Theis, Fabian J.
Hansbro, Philip M.
Skowasch, Dirk
Schultze, Joachim L.
author_sort Kapellos, Theodore S.
collection PubMed
description Systemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells in early disease stages remain ill defined. Chronic obstructive pulmonary disease (COPD) is a major respiratory disease characterized by small-airway inflammation, emphysema, and severe breathing difficulties. Using single-cell analyses we demonstrate that blood neutrophils are already increased in early-stage COPD, and changes in molecular and functional neutrophil states correlate with lung function decline. Assessing neutrophils and their bone marrow precursors in a murine cigarette smoke exposure model identified similar molecular changes in blood neutrophils and precursor populations that also occur in the blood and lung. Our study shows that systemic molecular alterations in neutrophils and their precursors are part of early-stage COPD, a finding to be further explored for potential therapeutic targets and biomarkers for early diagnosis and patient stratification.
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spelling pubmed-103208322023-07-06 Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease Kapellos, Theodore S. Baßler, Kevin Fujii, Wataru Nalkurthi, Christina Schaar, Anna C. Bonaguro, Lorenzo Pecht, Tal Galvao, Izabela Agrawal, Shobhit Saglam, Adem Dudkin, Erica Frishberg, Amit de Domenico, Elena Horne, Arik Donovan, Chantal Kim, Richard Y. Gallego-Ortega, David Gillett, Tessa E. Ansari, Meshal Schulte-Schrepping, Jonas Offermann, Nina Antignano, Ignazio Sivri, Burcu Lu, Wenying Eapen, Mathew S. van Uelft, Martina Osei-Sarpong, Collins van den Berge, Maarten Donker, Hylke C. Groen, Harry J.M. Sohal, Sukhwinder S. Klein, Johanna Schreiber, Tina Feißt, Andreas Yildirim, Ali Önder Schiller, Herbert B. Nawijn, Martijn C. Becker, Matthias Händler, Kristian Beyer, Marc Capasso, Melania Ulas, Thomas Hasenauer, Jan Pizarro, Carmen Theis, Fabian J. Hansbro, Philip M. Skowasch, Dirk Schultze, Joachim L. Cell Rep Article Systemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells in early disease stages remain ill defined. Chronic obstructive pulmonary disease (COPD) is a major respiratory disease characterized by small-airway inflammation, emphysema, and severe breathing difficulties. Using single-cell analyses we demonstrate that blood neutrophils are already increased in early-stage COPD, and changes in molecular and functional neutrophil states correlate with lung function decline. Assessing neutrophils and their bone marrow precursors in a murine cigarette smoke exposure model identified similar molecular changes in blood neutrophils and precursor populations that also occur in the blood and lung. Our study shows that systemic molecular alterations in neutrophils and their precursors are part of early-stage COPD, a finding to be further explored for potential therapeutic targets and biomarkers for early diagnosis and patient stratification. Cell Press 2023-05-26 /pmc/articles/PMC10320832/ /pubmed/37243592 http://dx.doi.org/10.1016/j.celrep.2023.112525 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Kapellos, Theodore S.
Baßler, Kevin
Fujii, Wataru
Nalkurthi, Christina
Schaar, Anna C.
Bonaguro, Lorenzo
Pecht, Tal
Galvao, Izabela
Agrawal, Shobhit
Saglam, Adem
Dudkin, Erica
Frishberg, Amit
de Domenico, Elena
Horne, Arik
Donovan, Chantal
Kim, Richard Y.
Gallego-Ortega, David
Gillett, Tessa E.
Ansari, Meshal
Schulte-Schrepping, Jonas
Offermann, Nina
Antignano, Ignazio
Sivri, Burcu
Lu, Wenying
Eapen, Mathew S.
van Uelft, Martina
Osei-Sarpong, Collins
van den Berge, Maarten
Donker, Hylke C.
Groen, Harry J.M.
Sohal, Sukhwinder S.
Klein, Johanna
Schreiber, Tina
Feißt, Andreas
Yildirim, Ali Önder
Schiller, Herbert B.
Nawijn, Martijn C.
Becker, Matthias
Händler, Kristian
Beyer, Marc
Capasso, Melania
Ulas, Thomas
Hasenauer, Jan
Pizarro, Carmen
Theis, Fabian J.
Hansbro, Philip M.
Skowasch, Dirk
Schultze, Joachim L.
Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease
title Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease
title_full Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease
title_fullStr Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease
title_full_unstemmed Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease
title_short Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease
title_sort systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320832/
https://www.ncbi.nlm.nih.gov/pubmed/37243592
http://dx.doi.org/10.1016/j.celrep.2023.112525
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