Cargando…

CIRS-LAS – a novel approach to increase transparency in laboratory animal science for improving animal welfare by reducing laboratory animal distress

The 3Rs principle is highly topical in animal-based research. These include, above all, new scientific methods for conducting experiments without an animal model, by using non-animal models (Replace), reducing the number of laboratory animals (Reduction) or taking measures to keep the stress on the...

Descripción completa

Detalles Bibliográficos
Autores principales: Enkelmann, Astrid, Bischoff, Sabine J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320850/
https://www.ncbi.nlm.nih.gov/pubmed/37415966
http://dx.doi.org/10.3389/fvets.2023.1155249
_version_ 1785068513649491968
author Enkelmann, Astrid
Bischoff, Sabine J.
author_facet Enkelmann, Astrid
Bischoff, Sabine J.
author_sort Enkelmann, Astrid
collection PubMed
description The 3Rs principle is highly topical in animal-based research. These include, above all, new scientific methods for conducting experiments without an animal model, by using non-animal models (Replace), reducing the number of laboratory animals (Reduction) or taking measures to keep the stress on the laboratory animal as low as possible (Refinement). Despite numerous modern alternative approaches, the complete replacement of animal experiments is not yet possible. The exchange in the team about the daily work with laboratory animals, about open questions and problems, contributes to a reflection of one’s own work and to a better understanding of the work of the others. CIRS-LAS (Critical Incident Reporting System in Laboratory Animal Science) represents a reporting system for incidents in laboratory animal science. It is urgently needed because the lack of transparency about incidents leads to the repetition of failed experiments. Negative experiences from animal-based experiments are often not mentioned in publications, and the fear of hostility is still very high. Therefore, a constructive approach to errors is not a matter of course. To overcome this barrier, CIRS-LAS was created as a web-based database. It addresses the areas of reduction and refinement of the 3Rs principle by providing a platform to collect and analyze incidents. CIRS-LAS is open to all individuals working with laboratory animals worldwide and currently exists with 303 registered members, 52 reports, and an average of 71 visitors per month. The development of CIRS-LAS shows, that an open and constructive error culture is difficult to establish. Nevertheless, the upload of a case report or the search in the database leads to an active reflection of critical occurrences. Thus, it is an important step towards more transparency in laboratory animal science. As expected, the collected events in the database concern different categories and animal species and are primarily reported by persons involved in an experiment. However, reliable conclusions about observed effects require further analysis and continuous collection of case reports. Looking at the development of CIRS-LAS, its high potential is shown in considering the 3Rs principle in daily scientific work.
format Online
Article
Text
id pubmed-10320850
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-103208502023-07-06 CIRS-LAS – a novel approach to increase transparency in laboratory animal science for improving animal welfare by reducing laboratory animal distress Enkelmann, Astrid Bischoff, Sabine J. Front Vet Sci Veterinary Science The 3Rs principle is highly topical in animal-based research. These include, above all, new scientific methods for conducting experiments without an animal model, by using non-animal models (Replace), reducing the number of laboratory animals (Reduction) or taking measures to keep the stress on the laboratory animal as low as possible (Refinement). Despite numerous modern alternative approaches, the complete replacement of animal experiments is not yet possible. The exchange in the team about the daily work with laboratory animals, about open questions and problems, contributes to a reflection of one’s own work and to a better understanding of the work of the others. CIRS-LAS (Critical Incident Reporting System in Laboratory Animal Science) represents a reporting system for incidents in laboratory animal science. It is urgently needed because the lack of transparency about incidents leads to the repetition of failed experiments. Negative experiences from animal-based experiments are often not mentioned in publications, and the fear of hostility is still very high. Therefore, a constructive approach to errors is not a matter of course. To overcome this barrier, CIRS-LAS was created as a web-based database. It addresses the areas of reduction and refinement of the 3Rs principle by providing a platform to collect and analyze incidents. CIRS-LAS is open to all individuals working with laboratory animals worldwide and currently exists with 303 registered members, 52 reports, and an average of 71 visitors per month. The development of CIRS-LAS shows, that an open and constructive error culture is difficult to establish. Nevertheless, the upload of a case report or the search in the database leads to an active reflection of critical occurrences. Thus, it is an important step towards more transparency in laboratory animal science. As expected, the collected events in the database concern different categories and animal species and are primarily reported by persons involved in an experiment. However, reliable conclusions about observed effects require further analysis and continuous collection of case reports. Looking at the development of CIRS-LAS, its high potential is shown in considering the 3Rs principle in daily scientific work. Frontiers Media S.A. 2023-06-21 /pmc/articles/PMC10320850/ /pubmed/37415966 http://dx.doi.org/10.3389/fvets.2023.1155249 Text en Copyright © 2023 Enkelmann and Bischoff. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Enkelmann, Astrid
Bischoff, Sabine J.
CIRS-LAS – a novel approach to increase transparency in laboratory animal science for improving animal welfare by reducing laboratory animal distress
title CIRS-LAS – a novel approach to increase transparency in laboratory animal science for improving animal welfare by reducing laboratory animal distress
title_full CIRS-LAS – a novel approach to increase transparency in laboratory animal science for improving animal welfare by reducing laboratory animal distress
title_fullStr CIRS-LAS – a novel approach to increase transparency in laboratory animal science for improving animal welfare by reducing laboratory animal distress
title_full_unstemmed CIRS-LAS – a novel approach to increase transparency in laboratory animal science for improving animal welfare by reducing laboratory animal distress
title_short CIRS-LAS – a novel approach to increase transparency in laboratory animal science for improving animal welfare by reducing laboratory animal distress
title_sort cirs-las – a novel approach to increase transparency in laboratory animal science for improving animal welfare by reducing laboratory animal distress
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320850/
https://www.ncbi.nlm.nih.gov/pubmed/37415966
http://dx.doi.org/10.3389/fvets.2023.1155249
work_keys_str_mv AT enkelmannastrid cirslasanovelapproachtoincreasetransparencyinlaboratoryanimalscienceforimprovinganimalwelfarebyreducinglaboratoryanimaldistress
AT bischoffsabinej cirslasanovelapproachtoincreasetransparencyinlaboratoryanimalscienceforimprovinganimalwelfarebyreducinglaboratoryanimaldistress