Protocadherin 20 maintains intestinal barrier function to protect against Crohn’s disease by targeting ATF6

BACKGROUND: Intestinal barrier dysfunction plays a central role in the pathological onset of Crohn’s disease. We identify the cadherin superfamily member protocadherin 20 (PCDH20) as a crucial factor in Crohn’s disease. Here we describe the function of PCDH20 and its mechanisms in gut homeostasis, b...

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Detalles Bibliográficos
Autores principales: Huang, Shanshan, Xie, Zhuo, Han, Jing, Wang, Huiling, Yang, Guang, Li, Manying, Zhou, Gaoshi, Wang, Ying, Li, Lixuan, Li, Li, Zeng, Zhirong, Yu, Jun, Chen, Minhu, Zhang, Shenghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320870/
https://www.ncbi.nlm.nih.gov/pubmed/37407995
http://dx.doi.org/10.1186/s13059-023-02991-0

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