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Exploring the clinical application value of peripheral blood T lymphocyte subset in patients with asymptomatic omicron infection
OBJECTIVE: To investigate the clinical significance and value of peripheral blood T lymphocyte subset in patients with asymptomatic novel coronavirus variant strains infection (OMICRON). METHODS: A retrospective analysis of 281 patients with asymptomatic OMICRON infection who were admitted and isola...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320873/ https://www.ncbi.nlm.nih.gov/pubmed/37408049 http://dx.doi.org/10.1186/s40001-023-01187-3 |
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author | Li, Tuantuan Xu, Jing Gao, Yong Wang, XiaoWu Xu, Yuanhong |
author_facet | Li, Tuantuan Xu, Jing Gao, Yong Wang, XiaoWu Xu, Yuanhong |
author_sort | Li, Tuantuan |
collection | PubMed |
description | OBJECTIVE: To investigate the clinical significance and value of peripheral blood T lymphocyte subset in patients with asymptomatic novel coronavirus variant strains infection (OMICRON). METHODS: A retrospective analysis of 281 patients with asymptomatic OMICRON infection who were admitted and isolated to the Fuyang Second People's Hospital from March to April 2022 was conducted. With 32 normal people as the control group, T lymphocytes of the two groups (CD3 + T, CD3 + CD4 + T, CD3 + CD8 + T) were analyzed and the differences between the two groups were analyzed. CD4 + T lymphocytes between patients with asymptomatic OMICRON infection and patients with mild COVID-19 infection in 2020 were analyzed and compared. Based on CD3 CD4 + T lymphocyte changes, lymphocyte reference range: CD3 CD4 + T lymphocyte count 404–1612/μL. Lower than 404 × 106/μL was defined as lymphocytopenia, patients were divided into the reduced group (138) and the normal group (143). The CT value of novel coronavirus nucleic acid (ORF1ab gene, N gene) and the time of viral shedding were compared between the two groups. RESULTS: Differences in number of CD3 + T cells, CD3 + CD4 + T cells, and CD3 + CD8 + T cells were significant between both groups (P < 0.05), which were significantly higher in the normal population than in the patients with asymptomatic OMICRON infection. There was no significant difference in CD4 + T lymphocytes between patients with asymptomatic OMICRON infection and patients with mild COVID-19 infection in 2020 (P < 0.05). The novel coronavirus nucleic CT value was significantly lower in the CD3CD4 + T lymphocyte-reduced group than in the CD3CD4 + T lymphocyte-normal group (P < 0.05). Moreover, the time of viral shedding was significantly longer in the reduced group compared with the normal group (P < 0.05). CONCLUSION: The changing characteristics of the peripheral blood T lymphocyte subset count in patients with asymptomatic OMICRON infections can provide an important basis for the diagnosis and outcome of the asymptomatic OMICRON infection. |
format | Online Article Text |
id | pubmed-10320873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-103208732023-07-06 Exploring the clinical application value of peripheral blood T lymphocyte subset in patients with asymptomatic omicron infection Li, Tuantuan Xu, Jing Gao, Yong Wang, XiaoWu Xu, Yuanhong Eur J Med Res Research OBJECTIVE: To investigate the clinical significance and value of peripheral blood T lymphocyte subset in patients with asymptomatic novel coronavirus variant strains infection (OMICRON). METHODS: A retrospective analysis of 281 patients with asymptomatic OMICRON infection who were admitted and isolated to the Fuyang Second People's Hospital from March to April 2022 was conducted. With 32 normal people as the control group, T lymphocytes of the two groups (CD3 + T, CD3 + CD4 + T, CD3 + CD8 + T) were analyzed and the differences between the two groups were analyzed. CD4 + T lymphocytes between patients with asymptomatic OMICRON infection and patients with mild COVID-19 infection in 2020 were analyzed and compared. Based on CD3 CD4 + T lymphocyte changes, lymphocyte reference range: CD3 CD4 + T lymphocyte count 404–1612/μL. Lower than 404 × 106/μL was defined as lymphocytopenia, patients were divided into the reduced group (138) and the normal group (143). The CT value of novel coronavirus nucleic acid (ORF1ab gene, N gene) and the time of viral shedding were compared between the two groups. RESULTS: Differences in number of CD3 + T cells, CD3 + CD4 + T cells, and CD3 + CD8 + T cells were significant between both groups (P < 0.05), which were significantly higher in the normal population than in the patients with asymptomatic OMICRON infection. There was no significant difference in CD4 + T lymphocytes between patients with asymptomatic OMICRON infection and patients with mild COVID-19 infection in 2020 (P < 0.05). The novel coronavirus nucleic CT value was significantly lower in the CD3CD4 + T lymphocyte-reduced group than in the CD3CD4 + T lymphocyte-normal group (P < 0.05). Moreover, the time of viral shedding was significantly longer in the reduced group compared with the normal group (P < 0.05). CONCLUSION: The changing characteristics of the peripheral blood T lymphocyte subset count in patients with asymptomatic OMICRON infections can provide an important basis for the diagnosis and outcome of the asymptomatic OMICRON infection. BioMed Central 2023-07-05 /pmc/articles/PMC10320873/ /pubmed/37408049 http://dx.doi.org/10.1186/s40001-023-01187-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Li, Tuantuan Xu, Jing Gao, Yong Wang, XiaoWu Xu, Yuanhong Exploring the clinical application value of peripheral blood T lymphocyte subset in patients with asymptomatic omicron infection |
title | Exploring the clinical application value of peripheral blood T lymphocyte subset in patients with asymptomatic omicron infection |
title_full | Exploring the clinical application value of peripheral blood T lymphocyte subset in patients with asymptomatic omicron infection |
title_fullStr | Exploring the clinical application value of peripheral blood T lymphocyte subset in patients with asymptomatic omicron infection |
title_full_unstemmed | Exploring the clinical application value of peripheral blood T lymphocyte subset in patients with asymptomatic omicron infection |
title_short | Exploring the clinical application value of peripheral blood T lymphocyte subset in patients with asymptomatic omicron infection |
title_sort | exploring the clinical application value of peripheral blood t lymphocyte subset in patients with asymptomatic omicron infection |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320873/ https://www.ncbi.nlm.nih.gov/pubmed/37408049 http://dx.doi.org/10.1186/s40001-023-01187-3 |
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