Glycyrrhiza polysaccharides inhibits PRRSV replication

Glycyrrhiza polysaccharide (GCP) is a natural plant active polysaccharide extracted from traditional Chinese medicine licorice. In this research, we studied the antiviral activity of glycyrrhiza polysaccharide against porcine reproductive and respiratory syndrome virus (PRRSV), a virus of the Arteri...

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Autores principales: Yang, Youbing, Liu, Yongjian, Lou, Ran, Lei, Ying, Li, Gan, Xu, Zhiqian, You, Xiangbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320881/
https://www.ncbi.nlm.nih.gov/pubmed/37408066
http://dx.doi.org/10.1186/s12985-023-02052-9
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author Yang, Youbing
Liu, Yongjian
Lou, Ran
Lei, Ying
Li, Gan
Xu, Zhiqian
You, Xiangbin
author_facet Yang, Youbing
Liu, Yongjian
Lou, Ran
Lei, Ying
Li, Gan
Xu, Zhiqian
You, Xiangbin
author_sort Yang, Youbing
collection PubMed
description Glycyrrhiza polysaccharide (GCP) is a natural plant active polysaccharide extracted from traditional Chinese medicine licorice. In this research, we studied the antiviral activity of glycyrrhiza polysaccharide against porcine reproductive and respiratory syndrome virus (PRRSV), a virus of the Arteriviridae family, with a high rate of variation and has caused huge economic losses to the pig industry in various countries since its discovery. Our results show that GCP can inhibit PRRSV replication in a dose-dependent manner. Furthermore, GCP could inhibit the mRNA expression of receptor genes CD163 and NF-κB p65 and promote the mRNA expression of the SLA-7 gene. Because of these results, GCP can be used as a candidate drug to prevent and treat PRRS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12985-023-02052-9.
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spelling pubmed-103208812023-07-06 Glycyrrhiza polysaccharides inhibits PRRSV replication Yang, Youbing Liu, Yongjian Lou, Ran Lei, Ying Li, Gan Xu, Zhiqian You, Xiangbin Virol J Research Glycyrrhiza polysaccharide (GCP) is a natural plant active polysaccharide extracted from traditional Chinese medicine licorice. In this research, we studied the antiviral activity of glycyrrhiza polysaccharide against porcine reproductive and respiratory syndrome virus (PRRSV), a virus of the Arteriviridae family, with a high rate of variation and has caused huge economic losses to the pig industry in various countries since its discovery. Our results show that GCP can inhibit PRRSV replication in a dose-dependent manner. Furthermore, GCP could inhibit the mRNA expression of receptor genes CD163 and NF-κB p65 and promote the mRNA expression of the SLA-7 gene. Because of these results, GCP can be used as a candidate drug to prevent and treat PRRS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12985-023-02052-9. BioMed Central 2023-07-05 /pmc/articles/PMC10320881/ /pubmed/37408066 http://dx.doi.org/10.1186/s12985-023-02052-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Yang, Youbing
Liu, Yongjian
Lou, Ran
Lei, Ying
Li, Gan
Xu, Zhiqian
You, Xiangbin
Glycyrrhiza polysaccharides inhibits PRRSV replication
title Glycyrrhiza polysaccharides inhibits PRRSV replication
title_full Glycyrrhiza polysaccharides inhibits PRRSV replication
title_fullStr Glycyrrhiza polysaccharides inhibits PRRSV replication
title_full_unstemmed Glycyrrhiza polysaccharides inhibits PRRSV replication
title_short Glycyrrhiza polysaccharides inhibits PRRSV replication
title_sort glycyrrhiza polysaccharides inhibits prrsv replication
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320881/
https://www.ncbi.nlm.nih.gov/pubmed/37408066
http://dx.doi.org/10.1186/s12985-023-02052-9
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