Mechanisms of metabolic stress induced cell death of human oligodendrocytes: relevance for progressive multiple sclerosis

Oligodendrocyte (OL) injury and loss are central features of evolving lesions in multiple sclerosis. Potential causative mechanisms of OL loss include metabolic stress within the lesion microenvironment. Here we use the injury response of primary human OLs (hOLs) to metabolic stress (reduced glucose...

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Detalles Bibliográficos
Autores principales: Fernandes, Milton Guilherme Forestieri, Mohammadnia, Abdulshakour, Pernin, Florian, Schmitz-Gielsdorf, Laura Eleonora, Hodgins, Caroline, Cui, Qiao-Ling, Yaqubi, Moein, Blain, Manon, Hall, Jeffery, Dudley, Roy, Srour, Myriam, Zandee, Stephanie E. J., Klement, Wendy, Prat, Alexandre, Stratton, Jo Anne, Rodriguez, Moses, Kuhlmann, Tanja, Moore, Wayne, Kennedy, Timothy E., Antel, Jack P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320974/
https://www.ncbi.nlm.nih.gov/pubmed/37408029
http://dx.doi.org/10.1186/s40478-023-01601-1

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