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Imaging the columnar functional organization of human area MT+ to axis-of-motion stimuli using VASO at 7 Tesla
Cortical columns of direction-selective neurons in the motion sensitive area (MT) have been successfully established as a microscopic feature of the neocortex in animals. The same property has been investigated at mesoscale (<1 mm) in the homologous brain area (hMT+, V5) in living humans by using...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321107/ https://www.ncbi.nlm.nih.gov/pubmed/37254796 http://dx.doi.org/10.1093/cercor/bhad151 |
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author | Pizzuti, Alessandra Huber, Laurentius (Renzo) Gulban, Omer Faruk Benitez-Andonegui, Amaia Peters, Judith Goebel, Rainer |
author_facet | Pizzuti, Alessandra Huber, Laurentius (Renzo) Gulban, Omer Faruk Benitez-Andonegui, Amaia Peters, Judith Goebel, Rainer |
author_sort | Pizzuti, Alessandra |
collection | PubMed |
description | Cortical columns of direction-selective neurons in the motion sensitive area (MT) have been successfully established as a microscopic feature of the neocortex in animals. The same property has been investigated at mesoscale (<1 mm) in the homologous brain area (hMT+, V5) in living humans by using ultra-high field functional magnetic resonance imaging (fMRI). Despite the reproducibility of the selective response to axis-of-motion stimuli, clear quantitative evidence for the columnar organization of hMT+ is still lacking. Using cerebral blood volume (CBV)-sensitive fMRI at 7 Tesla with submillimeter resolution and high spatial specificity to microvasculature, we investigate the columnar functional organization of hMT+ in 5 participants perceiving axis-of-motion stimuli for both blood oxygenation level dependent (BOLD) and vascular space occupancy (VASO) contrast mechanisms provided by the used slice-selective slab-inversion (SS-SI)-VASO sequence. With the development of a new searchlight algorithm for column detection, we provide the first quantitative columnarity map that characterizes the entire 3D hMT+ volume. Using voxel-wise measures of sensitivity and specificity, we demonstrate the advantage of using CBV-sensitive fMRI to detect mesoscopic cortical features by revealing higher specificity of axis-of-motion cortical columns for VASO as compared to BOLD contrast. These voxel-wise metrics also provide further insights on how to mitigate the highly debated draining veins effect. We conclude that using CBV–VASO fMRI together with voxel-wise measurements of sensitivity, specificity and columnarity offers a promising avenue to quantify the mesoscopic organization of hMT+ with respect to axis-of-motion stimuli. Furthermore, our approach and methodological developments are generalizable and applicable to other human brain areas where similar mesoscopic research questions are addressed. |
format | Online Article Text |
id | pubmed-10321107 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-103211072023-07-06 Imaging the columnar functional organization of human area MT+ to axis-of-motion stimuli using VASO at 7 Tesla Pizzuti, Alessandra Huber, Laurentius (Renzo) Gulban, Omer Faruk Benitez-Andonegui, Amaia Peters, Judith Goebel, Rainer Cereb Cortex Articles Cortical columns of direction-selective neurons in the motion sensitive area (MT) have been successfully established as a microscopic feature of the neocortex in animals. The same property has been investigated at mesoscale (<1 mm) in the homologous brain area (hMT+, V5) in living humans by using ultra-high field functional magnetic resonance imaging (fMRI). Despite the reproducibility of the selective response to axis-of-motion stimuli, clear quantitative evidence for the columnar organization of hMT+ is still lacking. Using cerebral blood volume (CBV)-sensitive fMRI at 7 Tesla with submillimeter resolution and high spatial specificity to microvasculature, we investigate the columnar functional organization of hMT+ in 5 participants perceiving axis-of-motion stimuli for both blood oxygenation level dependent (BOLD) and vascular space occupancy (VASO) contrast mechanisms provided by the used slice-selective slab-inversion (SS-SI)-VASO sequence. With the development of a new searchlight algorithm for column detection, we provide the first quantitative columnarity map that characterizes the entire 3D hMT+ volume. Using voxel-wise measures of sensitivity and specificity, we demonstrate the advantage of using CBV-sensitive fMRI to detect mesoscopic cortical features by revealing higher specificity of axis-of-motion cortical columns for VASO as compared to BOLD contrast. These voxel-wise metrics also provide further insights on how to mitigate the highly debated draining veins effect. We conclude that using CBV–VASO fMRI together with voxel-wise measurements of sensitivity, specificity and columnarity offers a promising avenue to quantify the mesoscopic organization of hMT+ with respect to axis-of-motion stimuli. Furthermore, our approach and methodological developments are generalizable and applicable to other human brain areas where similar mesoscopic research questions are addressed. Oxford University Press 2023-05-30 /pmc/articles/PMC10321107/ /pubmed/37254796 http://dx.doi.org/10.1093/cercor/bhad151 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Pizzuti, Alessandra Huber, Laurentius (Renzo) Gulban, Omer Faruk Benitez-Andonegui, Amaia Peters, Judith Goebel, Rainer Imaging the columnar functional organization of human area MT+ to axis-of-motion stimuli using VASO at 7 Tesla |
title | Imaging the columnar functional organization of human area MT+ to axis-of-motion stimuli using VASO at 7 Tesla |
title_full | Imaging the columnar functional organization of human area MT+ to axis-of-motion stimuli using VASO at 7 Tesla |
title_fullStr | Imaging the columnar functional organization of human area MT+ to axis-of-motion stimuli using VASO at 7 Tesla |
title_full_unstemmed | Imaging the columnar functional organization of human area MT+ to axis-of-motion stimuli using VASO at 7 Tesla |
title_short | Imaging the columnar functional organization of human area MT+ to axis-of-motion stimuli using VASO at 7 Tesla |
title_sort | imaging the columnar functional organization of human area mt+ to axis-of-motion stimuli using vaso at 7 tesla |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321107/ https://www.ncbi.nlm.nih.gov/pubmed/37254796 http://dx.doi.org/10.1093/cercor/bhad151 |
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