Targeted proximity-labelling of protein tyrosines via flavin-dependent photoredox catalysis with mechanistic evidence for a radical–radical recombination pathway

Flavin-based photocatalysts such as riboflavin tetraacetate (RFT) serve as a robust platform for light-mediated protein labelling via phenoxy radical-mediated tyrosine–biotin phenol coupling on live cells. To gain insight into this coupling reaction, we conducted detailed mechanistic analysis for RF...

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Detalles Bibliográficos
Autores principales: Hope, Taylor O., Reyes-Robles, Tamara, Ryu, Keun Ah, Mauries, Steven, Removski, Nicole, Maisonneuve, Jacinthe, Oslund, Rob C., Fadeyi, Olugbeminiyi O., Frenette, Mathieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321502/
https://www.ncbi.nlm.nih.gov/pubmed/37416718
http://dx.doi.org/10.1039/d3sc00638g

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