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Association of depressive symptoms and quality of life in Pakistani youth (15–24 years) with polycystic ovarian syndrome: a web-based analytical cross-sectional study
INTRODUCTION: Polycystic ovarian syndrome (PCOS) is associated with impaired quality of life (QOL) of individuals, predominantly in youth, who are most vulnerable to its impact. Psychological morbidity could be one of the factors influencing QOL. The study investigated the association between depres...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321523/ https://www.ncbi.nlm.nih.gov/pubmed/37415597 http://dx.doi.org/10.3389/fgwh.2023.967883 |
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author | Peerwani, Ghazal Rozi, Shafquat Lakhdir, Maryam Pyar Ali Zuberi, Nadeem Asad, Nargis |
author_facet | Peerwani, Ghazal Rozi, Shafquat Lakhdir, Maryam Pyar Ali Zuberi, Nadeem Asad, Nargis |
author_sort | Peerwani, Ghazal |
collection | PubMed |
description | INTRODUCTION: Polycystic ovarian syndrome (PCOS) is associated with impaired quality of life (QOL) of individuals, predominantly in youth, who are most vulnerable to its impact. Psychological morbidity could be one of the factors influencing QOL. The study investigated the association between depressive symptoms and QOL in Pakistani youth (15–24 years) with PCOS and determined other factors associated with QOL. METHODS: We conducted an analytical-cross-sectional survey on 213 single Pakistani females aged 15–24 years recruited via a web-based approach. Depression and QOL were assessed through Center-of-Epidemiological-Studies-Depression tool and Polycystic-ovarian-syndrome-quality-of-life-scale. Multiple-linear-regression was used to determine factors associated with QOL, and adjusted regression-coefficients along with a 95% confidence interval were reported. RESULTS: The mean QOL score: 2.9 ± 1.1. The domain of obesity had the lowest mean score (2.5 ± 1.6) whereas domain of hirsutism had the highest (3.2 ± 1.9). 172/213 (80%) participants were screened positive for depressive symptoms. Participants with depressive symptoms reported reduced mean QOL scores than respondents with no such symptoms (2.8 ± 1.0 vs. 3.4 ± 1.3, p < 0.001). No differences were found in overall QOL and individual domains between participants 15–19 years (n = 36, 17%) and participants >19–24 years (n = 177, 83%) (2.9 ± 1.1 vs. 2.9 ± 1.1) (p > 0.05). We found a significant interaction between depressive symptoms and PCOS duration, indicating that the estimated mean overall QOL score decreases by 25.1 (−36.6, −13.6) for every year increase in PCOS duration among participants screened positive for depressive symptoms. Furthermore, for those respondents who had family history of PCOS and were not satisfied with their healthcare provider treating PCOS, the estimated mean QOL score was 17.47 (−26.1, −8.8) lower than participants who had no family history of PCOS and were satisfied with their healthcare provider. Other factors associated with reduced quality of life included societal pressure to improve appearance affected by PCOS, parental criticism related to PCOS, education, socioeconomic status, working status and BMI. CONCLUSION: Depressive symptoms with increasing duration of PCOS were significantly associated with reduced QOL. Therefore, to improve the overall QOL of PCOS youth, screening and timely addressing of psychological morbidities should be considered. |
format | Online Article Text |
id | pubmed-10321523 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103215232023-07-06 Association of depressive symptoms and quality of life in Pakistani youth (15–24 years) with polycystic ovarian syndrome: a web-based analytical cross-sectional study Peerwani, Ghazal Rozi, Shafquat Lakhdir, Maryam Pyar Ali Zuberi, Nadeem Asad, Nargis Front Glob Womens Health Global Women's Health INTRODUCTION: Polycystic ovarian syndrome (PCOS) is associated with impaired quality of life (QOL) of individuals, predominantly in youth, who are most vulnerable to its impact. Psychological morbidity could be one of the factors influencing QOL. The study investigated the association between depressive symptoms and QOL in Pakistani youth (15–24 years) with PCOS and determined other factors associated with QOL. METHODS: We conducted an analytical-cross-sectional survey on 213 single Pakistani females aged 15–24 years recruited via a web-based approach. Depression and QOL were assessed through Center-of-Epidemiological-Studies-Depression tool and Polycystic-ovarian-syndrome-quality-of-life-scale. Multiple-linear-regression was used to determine factors associated with QOL, and adjusted regression-coefficients along with a 95% confidence interval were reported. RESULTS: The mean QOL score: 2.9 ± 1.1. The domain of obesity had the lowest mean score (2.5 ± 1.6) whereas domain of hirsutism had the highest (3.2 ± 1.9). 172/213 (80%) participants were screened positive for depressive symptoms. Participants with depressive symptoms reported reduced mean QOL scores than respondents with no such symptoms (2.8 ± 1.0 vs. 3.4 ± 1.3, p < 0.001). No differences were found in overall QOL and individual domains between participants 15–19 years (n = 36, 17%) and participants >19–24 years (n = 177, 83%) (2.9 ± 1.1 vs. 2.9 ± 1.1) (p > 0.05). We found a significant interaction between depressive symptoms and PCOS duration, indicating that the estimated mean overall QOL score decreases by 25.1 (−36.6, −13.6) for every year increase in PCOS duration among participants screened positive for depressive symptoms. Furthermore, for those respondents who had family history of PCOS and were not satisfied with their healthcare provider treating PCOS, the estimated mean QOL score was 17.47 (−26.1, −8.8) lower than participants who had no family history of PCOS and were satisfied with their healthcare provider. Other factors associated with reduced quality of life included societal pressure to improve appearance affected by PCOS, parental criticism related to PCOS, education, socioeconomic status, working status and BMI. CONCLUSION: Depressive symptoms with increasing duration of PCOS were significantly associated with reduced QOL. Therefore, to improve the overall QOL of PCOS youth, screening and timely addressing of psychological morbidities should be considered. Frontiers Media S.A. 2023-06-21 /pmc/articles/PMC10321523/ /pubmed/37415597 http://dx.doi.org/10.3389/fgwh.2023.967883 Text en © 2023 Peerwani, Rozi, Lakhdir, Zuberi and Asad. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Global Women's Health Peerwani, Ghazal Rozi, Shafquat Lakhdir, Maryam Pyar Ali Zuberi, Nadeem Asad, Nargis Association of depressive symptoms and quality of life in Pakistani youth (15–24 years) with polycystic ovarian syndrome: a web-based analytical cross-sectional study |
title | Association of depressive symptoms and quality of life in Pakistani youth (15–24 years) with polycystic ovarian syndrome: a web-based analytical cross-sectional study |
title_full | Association of depressive symptoms and quality of life in Pakistani youth (15–24 years) with polycystic ovarian syndrome: a web-based analytical cross-sectional study |
title_fullStr | Association of depressive symptoms and quality of life in Pakistani youth (15–24 years) with polycystic ovarian syndrome: a web-based analytical cross-sectional study |
title_full_unstemmed | Association of depressive symptoms and quality of life in Pakistani youth (15–24 years) with polycystic ovarian syndrome: a web-based analytical cross-sectional study |
title_short | Association of depressive symptoms and quality of life in Pakistani youth (15–24 years) with polycystic ovarian syndrome: a web-based analytical cross-sectional study |
title_sort | association of depressive symptoms and quality of life in pakistani youth (15–24 years) with polycystic ovarian syndrome: a web-based analytical cross-sectional study |
topic | Global Women's Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321523/ https://www.ncbi.nlm.nih.gov/pubmed/37415597 http://dx.doi.org/10.3389/fgwh.2023.967883 |
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